The association of pulmonary function with carotid atherosclerosis in older Chinese: Guangzhou Biobank Cohort Study-CVD Subcohort

Research output: Contribution to journalArticlepeer-review

Authors

  • Jing Pan
  • Lin Xu
  • Shao Xi Cai
  • Chao Qiang Jiang
  • Hai Jin Zhao
  • Wei Sen Zhang
  • Ya Li Jin
  • Jie Ming Lin
  • Tai Hing Lam

Abstract

Background

Evidence describing the association between pulmonary function and carotid atherosclerosis has been inconclusive and the role of smoking in this association is unclear. We therefore examined this association in the Guangzhou Biobank Cohort Study-CVD Subcohort.

Methods

Common carotid artery (CCA) intima-media thickness (IMT) and carotid plaques were measured by B-mode ultrasonography and lung function by spirometry using a turbine flowmeter. Chronic obstructive pulmonary disease (COPD) was defined as the ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) of less than 0.70. Predicted FEV1 and FVC were derived using equations for Chinese.

Results

Of 1625 participants aged 50+ years, 382 (23.5%) had evidence of carotid plaque. The mean CCA-IMT was higher in those with COPD than those without (0.82±0.29mm versus 0.76±0.31mm, P=0.02). We found no evidence that the association of pulmonary function with CCA-IMT varied by smoking status (P values interaction: 0.23-0.83). After adjustment for a wide range of potential confounders, the increased risks of thickened CCA-IMT (CCA-IMT ≥1.0mm) in those with COPD became marginally nonsignificant (adjusted odds ratio (OR) 1.45, 95% confidence interval (CI) 0.91-2.29; P=0.12). Compared to those in the highest tertile, participants in the lowest tertile of FEV1 observed to predicted ratio had increased risk of thickened CCA-IMT (adjusted OR 2.18, 95% CI 1.42-3.34) and carotid plaque (adjusted OR 1.50, 95% CI 1.08-2.09), while participants in the lowest tertile of FVC observed to predicted ratio had increased risk of thickened CCA-IMT (adjusted OR 2.29, 95% CI 1.46-3.58), but the adjusted OR for carotid plaque was marginally nonsignificant (adjusted OR 1.29, 95% CI 0.93-1.80; P =0.13).

Conclusion

Independent of smoking status, poor pulmonary function was dose-dependently associated with carotid atherosclerosis in older Chinese.

Details

Original languageEnglish
JournalAtherosclerosis
Early online date3 Oct 2015
Publication statusE-pub ahead of print - 3 Oct 2015

Keywords

  • Pulmonary function, chronic obstructive pulmonary disease, intimal-medial thickness, carotid atherosclerosis