The application of tribology in assessing texture perception of oral liquid medicines

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Colleges, School and Institutes

Abstract

The palatability of medicines is likely to have a significant impact on patient adherence and consequently, on the safety and efficacy of a medicinal product. Palatability encompasses properties of medicines not limited to taste including swallowability (e.g. size, shape, texture). However, there has been limited work undertaken to measure the texture of medicines and how this may affect palatability and subsequent adherence. Tribology offers an understanding of oral processes and can allow physical properties of materials to be linked to "mouthfeel". This paper describes a preliminary application of tribology to oral liquid medicines and demonstrates that this technique is useful in the development of future oral liquid medicines.

Bibliographic note

Copyright © 2015 Elsevier B.V. All rights reserved.

Details

Original languageEnglish
Pages (from-to)277-81
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume479
Issue number2
Early online date6 Jan 2015
Publication statusPublished - 20 Feb 2015

Keywords

  • Tribology, Texture, Mouthfeel, Medicine