The activation of the CGRP receptor

Research output: Contribution to journalArticle

Authors

  • James Barwell
  • Alex C Conner
  • Bruck Taddese
  • Shabana Vohra
  • Christopher A Reynolds
  • David R Poyner

Colleges, School and Institutes

Abstract

The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

Details

Original languageEnglish
Pages (from-to)180-4
Number of pages5
JournalBiochemical Society Transactions
Volume41
Issue number1
Publication statusPublished - 1 Feb 2013

Keywords

  • Crystallography, X-Ray, Protein Binding, Receptors, Calcitonin Gene-Related Peptide