The activation of the CGRP receptor

James Barwell; Mark Wheatley; Alex C Conner; Bruck Taddese; Shabana Vohra; Christopher A Reynolds; David R Poyner

doi:10.1042/BST20120251

The activation of the CGRP receptor

James Barwell, Mark Wheatley, Alex C Conner, Bruck Taddese, Shabana Vohra, Christopher A Reynolds, David R Poyner

Biosciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

Original language	English
Pages (from-to)	180-4
Number of pages	5
Journal	Biochemical Society Transactions
Volume	41
Issue number	1
DOIs	https://doi.org/10.1042/BST20120251
Publication status	Published - 1 Feb 2013

Keywords

Crystallography, X-Ray
Protein Binding
Receptors, Calcitonin Gene-Related Peptide

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abstract = "The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.",

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AU - Barwell, James

AU - Wheatley, Mark

AU - Conner, Alex C

AU - Taddese, Bruck

AU - Vohra, Shabana

AU - Reynolds, Christopher A

AU - Poyner, David R

PY - 2013/2/1

Y1 - 2013/2/1

N2 - The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

AB - The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is an example of a family B GPCR. Unlike family A GPCRs, little is known about how these receptors are activated by their endogenous ligands. This review considers what is known about the activation of family B GPCRs and then considers how this might be applied to CLR, particularly in light of new knowledge of the crystal structures of family A GPCRs.

KW - Crystallography, X-Ray

KW - Protein Binding

KW - Receptors, Calcitonin Gene-Related Peptide

U2 - 10.1042/BST20120251

DO - 10.1042/BST20120251

M3 - Article

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SN - 1470-8752

VL - 41

SP - 180

EP - 184

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

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The activation of the CGRP receptor

Abstract

Keywords

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