The 8q24 rs6983267G variant is associated with increased thyroid cancer risk

Research output: Contribution to specialist publicationArticle

Standard

The 8q24 rs6983267G variant is associated with increased thyroid cancer risk. / Sahasrabudhe, Ruta; Carvajal-Carmona, LG; TCUKIN Consortium; Colorectal Tumour Gene Identification (CORGI) Consortium.

In: Endocrine-related cancer, Vol. 22, No. 5, 10.2015, p. 841-849.

Research output: Contribution to specialist publicationArticle

Harvard

Sahasrabudhe, R, Carvajal-Carmona, LG, TCUKIN Consortium & Colorectal Tumour Gene Identification (CORGI) Consortium 2015, 'The 8q24 rs6983267G variant is associated with increased thyroid cancer risk' Endocrine-related cancer, vol. 22, no. 5, pp. 841-849. https://doi.org/10.1530/ERC-15-0081

APA

Sahasrabudhe, R., Carvajal-Carmona, LG., TCUKIN Consortium, & Colorectal Tumour Gene Identification (CORGI) Consortium (2015). The 8q24 rs6983267G variant is associated with increased thyroid cancer risk. Endocrine-related cancer, 22(5), 841-849. https://doi.org/10.1530/ERC-15-0081

Vancouver

Sahasrabudhe R, Carvajal-Carmona LG, TCUKIN Consortium, Colorectal Tumour Gene Identification (CORGI) Consortium. The 8q24 rs6983267G variant is associated with increased thyroid cancer risk. Endocrine-related cancer. 2015 Oct;22(5):841-849. https://doi.org/10.1530/ERC-15-0081

Author

Sahasrabudhe, Ruta ; Carvajal-Carmona, LG ; TCUKIN Consortium ; Colorectal Tumour Gene Identification (CORGI) Consortium. / The 8q24 rs6983267G variant is associated with increased thyroid cancer risk. In: Endocrine-related cancer. 2015 ; Vol. 22, No. 5. pp. 841-849.

Bibtex

@misc{7aee77f0376b4bfaada9baa2cc742885,
title = "The 8q24 rs6983267G variant is associated with increased thyroid cancer risk",
abstract = "The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95% CI: 1.11–1.27, P=4.03×10−7), Japan (OR=1.20, 95% CI: 1.03–1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95% CI: 0.99–1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10−7, OR=1.13, 95% CI: 1.08–1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13%. ",
keywords = "tyroid cancer, rs6983267G, 8q24, genetic susceptibility",
author = "Ruta Sahasrabudhe and LG Carvajal-Carmona and Hesham Mehanna and {TCUKIN Consortium} and {Colorectal Tumour Gene Identification (CORGI) Consortium}",
year = "2015",
month = oct,
doi = "10.1530/ERC-15-0081",
language = "English",
volume = "22",
pages = "841--849",
journal = "Endocrine-related cancer",
issn = "1351-0088",
publisher = "BioScientifica",

}

RIS

TY - GEN

T1 - The 8q24 rs6983267G variant is associated with increased thyroid cancer risk

AU - Sahasrabudhe, Ruta

AU - Carvajal-Carmona, LG

AU - Mehanna, Hesham

AU - TCUKIN Consortium

AU - Colorectal Tumour Gene Identification (CORGI) Consortium

PY - 2015/10

Y1 - 2015/10

N2 - The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95% CI: 1.11–1.27, P=4.03×10−7), Japan (OR=1.20, 95% CI: 1.03–1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95% CI: 0.99–1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10−7, OR=1.13, 95% CI: 1.08–1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13%.

AB - The G allele of the rs6983267 single-nucleotide polymorphism, located on chromosome 8q24, has been associated with increased risk of several cancer types. The association between rs6983267G and thyroid cancer (TC) has been tested in different populations, mostly of European ancestry, and has led to inconclusive results. While significant associations have been reported in the British and Polish populations, no association has been detected in populations from Spain, Italy and the USA. To further investigate the role of rs6983267G in TC susceptibility, we evaluated rs6983267 genotypes in three populations of different continental ancestry (British Isles, Colombia and Japan), providing a total of 3067 cases and 8575 controls. We detected significant associations between rs6983267G and TC in the British Isles (odds ratio (OR)=1.19, 95% CI: 1.11–1.27, P=4.03×10−7), Japan (OR=1.20, 95% CI: 1.03–1.41, P=0.022) and a borderline significant association of similar effect direction and size in Colombia (OR=1.19, 95% CI: 0.99–1.44, P=0.069). A meta-analysis of our multi-ethnic study and previously published non-overlapping datasets, which included a total of 5484 cases and 12 594 controls, confirmed the association between rs6983267G and TC (P=1.23×10−7, OR=1.13, 95% CI: 1.08–1.18). Our results therefore support the notion that rs6983267G is a bona fide TC risk variant that increases the risk of disease by ∼13%.

KW - tyroid cancer

KW - rs6983267G

KW - 8q24

KW - genetic susceptibility

U2 - 10.1530/ERC-15-0081

DO - 10.1530/ERC-15-0081

M3 - Article

VL - 22

SP - 841

EP - 849

JO - Endocrine-related cancer

JF - Endocrine-related cancer

SN - 1351-0088

ER -