The 4 D's of pellagra and progress

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Colleges, School and Institutes


Nicotinamide homeostasis is a candidate common denominator to explain smooth transitions, whether demographic, epidemiological or economic. This ‘NAD world’, dependent on hydrogen-based energy, is not widely recognised as it is neither measured nor viewed from a sufficiently multi-genomic or historical perspective. Reviewing the importance of meat and nicotinamide balances during our co-evolution, recent history suggests that populations only modernise and age well with low fertility on a suitably balanced diet. Imbalances on the low meat side lead to an excess of infectious disease, short lives and boom-bust demographics. On the high side, meat has led to an excess of degenerative, allergic and metabolic disease and low fertility. A ‘Goldilocks’ diet derived from mixed and sustainable farming (preserving the topsoil) allows for high intellectual capital, height and good health with controlled population growth resulting in economic growth and prosperity. Implementing meat equity worldwide could lead to progress for future generations on ‘spaceship’ earth by establishing control over population quality, thermostat and biodiversity, if it is not already too late.

Bibliographic note

© The Author(s) 2020.


Original languageEnglish
Pages (from-to)1-12
JournalInternational Journal of Tryptophan Research
Publication statusPublished - 16 Apr 2020


  • CO emissions, COVID-19, Climate change, NAD worlds, Parkinson disease, anthropocene, coronavirus, deaths of despair, demographic transition, disease X, disease transitions, meat, metabolic rift, new levellers, nicotinamide, protonopathy

ASJC Scopus subject areas