Tetraspanins in human epithelial malignancies.

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Tetraspanins in human epithelial malignancies. / Romanska, Hanna; Berditchevski, Fedor.

In: Journal of Pathology, 15.09.2010.

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@article{18064ee72a5147dbb5d9891f34c55430,
title = "Tetraspanins in human epithelial malignancies.",
abstract = "Transmembrane proteins of the tetraspanin superfamily are implicated in a broad spectrum of cellular processes in many biological systems in both health and disease. Tetraspanins form specialized membrane microdomains on the cell surface which control cell proliferation and migration through various adhesion and growth factor receptors. Recent extensive research has shown that expression of various tetraspanins and their associated partners is deregulated in human malignancies. Although, for the most part, the degree of involvement of tetraspanins in carcinogenesis remains to be established, increasing evidence suggests that these proteins might be of clinical significance in at least some malignancies. Here we provide a comprehensive review of the existing data on expression of tetraspanins in breast cancer and other human epithelial tumours, with an emphasis on their value as potential prognostic markers. Copyright {\textcopyright} 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.",
author = "Hanna Romanska and Fedor Berditchevski",
year = "2010",
month = sep,
day = "15",
doi = "10.1002/path.2779",
language = "English",
journal = "Journal of Pathology",
issn = "0022-3417",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Tetraspanins in human epithelial malignancies.

AU - Romanska, Hanna

AU - Berditchevski, Fedor

PY - 2010/9/15

Y1 - 2010/9/15

N2 - Transmembrane proteins of the tetraspanin superfamily are implicated in a broad spectrum of cellular processes in many biological systems in both health and disease. Tetraspanins form specialized membrane microdomains on the cell surface which control cell proliferation and migration through various adhesion and growth factor receptors. Recent extensive research has shown that expression of various tetraspanins and their associated partners is deregulated in human malignancies. Although, for the most part, the degree of involvement of tetraspanins in carcinogenesis remains to be established, increasing evidence suggests that these proteins might be of clinical significance in at least some malignancies. Here we provide a comprehensive review of the existing data on expression of tetraspanins in breast cancer and other human epithelial tumours, with an emphasis on their value as potential prognostic markers. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

AB - Transmembrane proteins of the tetraspanin superfamily are implicated in a broad spectrum of cellular processes in many biological systems in both health and disease. Tetraspanins form specialized membrane microdomains on the cell surface which control cell proliferation and migration through various adhesion and growth factor receptors. Recent extensive research has shown that expression of various tetraspanins and their associated partners is deregulated in human malignancies. Although, for the most part, the degree of involvement of tetraspanins in carcinogenesis remains to be established, increasing evidence suggests that these proteins might be of clinical significance in at least some malignancies. Here we provide a comprehensive review of the existing data on expression of tetraspanins in breast cancer and other human epithelial tumours, with an emphasis on their value as potential prognostic markers. Copyright © 2010 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

U2 - 10.1002/path.2779

DO - 10.1002/path.2779

M3 - Article

C2 - 20938929

JO - Journal of Pathology

JF - Journal of Pathology

SN - 0022-3417

ER -