Tetraspanin CD151 plays a key role in skin squamous cell carcinoma

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Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. / Li, Q; Yang, X H; Xu, F; Sharma, C; Wang, H-X; Knoblich, K; Rabinovitz, I; Granter, S R; Hemler, M E.

In: Oncogene, Vol. 32, No. 14, 04.04.2013, p. 1772-83.

Research output: Contribution to journalArticle

Harvard

Li, Q, Yang, XH, Xu, F, Sharma, C, Wang, H-X, Knoblich, K, Rabinovitz, I, Granter, SR & Hemler, ME 2013, 'Tetraspanin CD151 plays a key role in skin squamous cell carcinoma', Oncogene, vol. 32, no. 14, pp. 1772-83. https://doi.org/10.1038/onc.2012.205

APA

Li, Q., Yang, X. H., Xu, F., Sharma, C., Wang, H-X., Knoblich, K., Rabinovitz, I., Granter, S. R., & Hemler, M. E. (2013). Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. Oncogene, 32(14), 1772-83. https://doi.org/10.1038/onc.2012.205

Vancouver

Author

Li, Q ; Yang, X H ; Xu, F ; Sharma, C ; Wang, H-X ; Knoblich, K ; Rabinovitz, I ; Granter, S R ; Hemler, M E. / Tetraspanin CD151 plays a key role in skin squamous cell carcinoma. In: Oncogene. 2013 ; Vol. 32, No. 14. pp. 1772-83.

Bibtex

@article{cb6bd851d6484413b298e5b0dff10b9b,
title = "Tetraspanin CD151 plays a key role in skin squamous cell carcinoma",
abstract = "Here we provide the first evidence that tetraspanin CD151 can support de novo carcinogenesis. During two-stage mouse skin chemical carcinogenesis, CD151 reduces tumor lag time and increases incidence, multiplicity, size and progression to malignant squamous cell carcinoma (SCC), while supporting both cell survival during tumor initiation and cell proliferation during the promotion phase. In human skin SCC, CD151 expression is selectively elevated compared with other skin cancer types. CD151 support of keratinocyte survival and proliferation may depend on activation of transcription factor STAT3 (signal transducers and activators of transcription), a regulator of cell proliferation and apoptosis. CD151 also supports protein kinase C (PKC)α-α6β4 integrin association and PKC-dependent β4 S1424 phosphorylation, while regulating α6β4 distribution. CD151-PKCα effects on integrin β4 phosphorylation and subcellular localization are consistent with epithelial disruption to a less polarized, more invasive state. CD151 ablation, while minimally affecting normal cell and normal mouse functions, markedly sensitized mouse skin and epidermoid cells to chemicals/drugs including 7,12-dimethylbenz[α]anthracene (mutagen) and camptothecin (topoisomerase inhibitor), as well as to agents targeting epidermal growth factor receptor, PKC, Jak2/Tyk2 and STAT3. Hence, CD151 'co-targeting' may be therapeutically beneficial. These findings not only support CD151 as a potential tumor target, but also should apply to other cancers utilizing CD151/laminin-binding integrin complexes.",
keywords = "9,10-Dimethyl-1,2-benzanthracene, Animals, Antigens, CD151, Apoptosis, Blotting, Western, Carcinogens, Carcinoma, Squamous Cell, Cell Proliferation, Cell Transformation, Neoplastic, Cyclic AMP-Dependent Protein Kinase Catalytic Subunits, Fluorescent Antibody Technique, Humans, Immunoenzyme Techniques, Integrin alpha6beta4, Mice, Mice, Knockout, Phosphorylation, STAT3 Transcription Factor, Signal Transduction, Skin Neoplasms, Tumor Cells, Cultured",
author = "Q Li and Yang, {X H} and F Xu and C Sharma and H-X Wang and K Knoblich and I Rabinovitz and Granter, {S R} and Hemler, {M E}",
year = "2013",
month = apr,
day = "4",
doi = "10.1038/onc.2012.205",
language = "English",
volume = "32",
pages = "1772--83",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "14",

}

RIS

TY - JOUR

T1 - Tetraspanin CD151 plays a key role in skin squamous cell carcinoma

AU - Li, Q

AU - Yang, X H

AU - Xu, F

AU - Sharma, C

AU - Wang, H-X

AU - Knoblich, K

AU - Rabinovitz, I

AU - Granter, S R

AU - Hemler, M E

PY - 2013/4/4

Y1 - 2013/4/4

N2 - Here we provide the first evidence that tetraspanin CD151 can support de novo carcinogenesis. During two-stage mouse skin chemical carcinogenesis, CD151 reduces tumor lag time and increases incidence, multiplicity, size and progression to malignant squamous cell carcinoma (SCC), while supporting both cell survival during tumor initiation and cell proliferation during the promotion phase. In human skin SCC, CD151 expression is selectively elevated compared with other skin cancer types. CD151 support of keratinocyte survival and proliferation may depend on activation of transcription factor STAT3 (signal transducers and activators of transcription), a regulator of cell proliferation and apoptosis. CD151 also supports protein kinase C (PKC)α-α6β4 integrin association and PKC-dependent β4 S1424 phosphorylation, while regulating α6β4 distribution. CD151-PKCα effects on integrin β4 phosphorylation and subcellular localization are consistent with epithelial disruption to a less polarized, more invasive state. CD151 ablation, while minimally affecting normal cell and normal mouse functions, markedly sensitized mouse skin and epidermoid cells to chemicals/drugs including 7,12-dimethylbenz[α]anthracene (mutagen) and camptothecin (topoisomerase inhibitor), as well as to agents targeting epidermal growth factor receptor, PKC, Jak2/Tyk2 and STAT3. Hence, CD151 'co-targeting' may be therapeutically beneficial. These findings not only support CD151 as a potential tumor target, but also should apply to other cancers utilizing CD151/laminin-binding integrin complexes.

AB - Here we provide the first evidence that tetraspanin CD151 can support de novo carcinogenesis. During two-stage mouse skin chemical carcinogenesis, CD151 reduces tumor lag time and increases incidence, multiplicity, size and progression to malignant squamous cell carcinoma (SCC), while supporting both cell survival during tumor initiation and cell proliferation during the promotion phase. In human skin SCC, CD151 expression is selectively elevated compared with other skin cancer types. CD151 support of keratinocyte survival and proliferation may depend on activation of transcription factor STAT3 (signal transducers and activators of transcription), a regulator of cell proliferation and apoptosis. CD151 also supports protein kinase C (PKC)α-α6β4 integrin association and PKC-dependent β4 S1424 phosphorylation, while regulating α6β4 distribution. CD151-PKCα effects on integrin β4 phosphorylation and subcellular localization are consistent with epithelial disruption to a less polarized, more invasive state. CD151 ablation, while minimally affecting normal cell and normal mouse functions, markedly sensitized mouse skin and epidermoid cells to chemicals/drugs including 7,12-dimethylbenz[α]anthracene (mutagen) and camptothecin (topoisomerase inhibitor), as well as to agents targeting epidermal growth factor receptor, PKC, Jak2/Tyk2 and STAT3. Hence, CD151 'co-targeting' may be therapeutically beneficial. These findings not only support CD151 as a potential tumor target, but also should apply to other cancers utilizing CD151/laminin-binding integrin complexes.

KW - 9,10-Dimethyl-1,2-benzanthracene

KW - Animals

KW - Antigens, CD151

KW - Apoptosis

KW - Blotting, Western

KW - Carcinogens

KW - Carcinoma, Squamous Cell

KW - Cell Proliferation

KW - Cell Transformation, Neoplastic

KW - Cyclic AMP-Dependent Protein Kinase Catalytic Subunits

KW - Fluorescent Antibody Technique

KW - Humans

KW - Immunoenzyme Techniques

KW - Integrin alpha6beta4

KW - Mice

KW - Mice, Knockout

KW - Phosphorylation

KW - STAT3 Transcription Factor

KW - Signal Transduction

KW - Skin Neoplasms

KW - Tumor Cells, Cultured

U2 - 10.1038/onc.2012.205

DO - 10.1038/onc.2012.205

M3 - Article

C2 - 22824799

VL - 32

SP - 1772

EP - 1783

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 14

ER -