Temper outbursts in Lowe syndrome: Characteristics, sequence, environmental context and comparison to Prader-Willi syndrome

Research output: Contribution to journalArticlepeer-review


Colleges, School and Institutes

External organisations

  • Coventry University
  • Aston University


BACKGROUND: There is limited research into the nature and aetiology of temper outbursts in people with intellectual disabilities. In this study, we describe the phenomenology and environmental context of temper outbursts in Lowe syndrome, a rare genetic syndrome in which outbursts are purportedly frequent.

METHOD: A temper outburst interview (TOI) was conducted with caregivers of seventeen individuals with Lowe syndrome to generate an account of the behavioural sequence, common antecedents and consequences of temper outbursts, and to enable comparisons with similar work on Prader-Willi syndrome.

RESULTS: Outbursts in Lowe syndrome were frequently triggered by thwarted goal-directed behaviour and were associated with high levels of physical aggression and property destruction.

CONCLUSIONS: Form and sequence of outbursts showed similarities to Prader-Willi syndrome and to behaviours reported in literature on typically developing children. The results highlight the importance of considering shared aetiology as well as syndrome-specific pathways in the development of outbursts.

Bibliographic note

© 2019 The Authors. Journal of Applied Research in Intellectual Disabilities Published by John Wiley & Sons Ltd.


Original languageEnglish
Pages (from-to)1216-1227
Number of pages12
JournalJournal of Applied Research in Intellectual Disabilities
Issue number5
Publication statusPublished - 1 Sep 2019


  • Adolescent, Adult, Aggression/physiology, Child, Humans, Male, Oculocerebrorenal Syndrome/physiopathology, Prader-Willi Syndrome/physiopathology, Problem Behavior, Qualitative Research, Young Adult