Projects per year
Abstract
This review discusses how the T-cell compartment in common variable immunodeficiency is marked by the premature arrest in thymic output, leading to T-cell exhaustion and immune dysregulation. Although B cells have been the main focus of the disorder, ample experimental data suggest that T-cell abnormalities can be seen in a large proportion of Freiburg Group 1a patients and those suffering from inflammatory complications. The reductions in T-cell receptor excision circles, naïve T cells, invariant NKT cells and regulatory T cells suggest a diminished thymic output, while CD8 T cells are driven towards exhaustion either via an antigen-dependent or an antigen-independent manner. The theoretical risk of anti-T-cell therapies is discussed, highlighting the need for an international effort in generating longitudinal data in addition to better-defined underlying molecular characterisation.
Original language | English |
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Pages (from-to) | 672-676 |
Journal | Journal of Clinical Pathology |
Volume | 69 |
Issue number | 8 |
Early online date | 6 May 2016 |
DOIs | |
Publication status | Published - Aug 2016 |
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Dive into the research topics of 'T-cell abnormalities in common variable immunodeficiency: the hidden defect'. Together they form a unique fingerprint.Projects
- 1 Finished
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Antigen Receptor Diversity and Autoantibody Characterisation in Common Variable Immunodeficiency
Wong, G., Cobbold, M. & Lane, P.
1/10/12 → 30/09/15
Project: Research