Targeting the transcription factor Myb by small-molecule inhibitors

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

The transcription factor Myb is a key regulator of hematopoietic cell proliferation, differentiation, and survival and has been implicated in the development of leukemia and several other human cancers. Pharmacological inhibition of Myb is therefore emerging as a potential therapeutic strategy. Recently, the first low-molecular-weight compounds that show Myb inhibitory activity have been identified. Characterization of these compounds suggests disruption of the protein–protein–interaction of Myb and the coactivator p300 as a suitable strategy to inhibit Myb.

Details

Original languageEnglish
Pages (from-to)31-35
JournalExperimental Hematology
Volume47
Early online date23 Dec 2016
Publication statusPublished - 1 Mar 2017