Target highlights in CASP13: experimental target structures through the eyes of their authors

Research output: Contribution to journalArticlepeer-review

Authors

  • Rosalba Lepore
  • Andriy Kryshtafovych
  • Markus Alahuhta
  • Harshul A. Veraszto
  • Yannick J. Bomble
  • Joshua C. Bufton
  • Alex N. Bullock
  • Cody Caba
  • Hongnan Cao
  • Owen R. Davies
  • Ambroise Desfosses
  • Matthew Dunne
  • Krzysztof Fidelis
  • Celia W. Goulding
  • Manickam Gurusaran
  • Irina Gutsche
  • Christopher J. Harding
  • Marcus D. Hartmann
  • Christopher S. Hayes
  • Andrzej Joachimiak
  • Petr G. Leiman
  • Peter Loppnau
  • Vladimir V. Lunin
  • Karolina Michalska
  • Ignacio Mir‐sanchis
  • Alok Mitra
  • John Moult
  • George N. Phillips Jr
  • Daniel M. Pinkas
  • Phoebe A. Rice
  • Yufeng Tong
  • Maya Topf
  • Jonathan D. Walton
  • Torsten Schwede

Colleges, School and Institutes

External organisations

  • BSC‐CNS Barcelona Supercomputing Center Barcelona Spain
  • Genome CenterUniversity of California Davis California
  • Biosciences CenterNational Renewable Energy Laboratory Golden Colorado
  • Department of Protein EvolutionMax Planck Institute for Developmental Biology Tübingen Germany
  • School of BiochemistryUniversity of Bristol Bristol UK
  • Nuffield Department of Medicine; Structural Genomics ConsortiumUniversity of Oxford Oxford UK
  • Department of Chemistry and BiochemistryUniversity of Windsor Windsor Ontario Canada
  • Great Lakes Bioenergy Research CenterUniversity of Wisconsin Madison Wisconsin
  • Newcastle University
  • Institut de Biologie StructuraleUniversité Grenoble Alpes, CEA, CNRS Grenoble France
  • Department of Health Science & Technology, Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 9, Zurich, 8092, Switzerland.
  • Department of Molecular Biology and Biochemistry; Pharmaceutical SciencesUniversity of California Irvine Irvine California
  • Department of Molecular, Cellular and Developmental Biology, Biomolecular Science and Engineering ProgramUniversity of California Santa Barbara California
  • Department of Biochemistry and Molecular BiologyUniversity of Chicago Chicago Illinois
  • Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular BiophysicsUniversity of Texas Medical Branch Galveston Texas
  • Structural Genomics ConsortiumUniversity of Toronto Toronto Ontario Canada
  • Structural Biology Center, Biosciences DivisionMidwest Center for Structural Genomics Argonne
  • University of Illinois
  • School of Biological SciencesUniversity of Auckland Auckland New Zealand
  • Institute for Bioscience and Biotechnology Research, Department of Cell Biology and Molecular geneticsUniversity of Maryland Rockville Maryland USA
  • Birkbeck, University of London
  • Great Lakes Bioenergy Research Center and Department of Plant BiologyMichigan State University East Lansing Michigan
  • University of Basel
  • Department of BioSciencesRice University Houston Texas

Abstract

The functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP13 experiment.

Details

Original languageEnglish
Pages (from-to)1037-1057
Number of pages21
JournalProteins: structure, function, and bioinformatics
Volume87
Issue number12
Early online date9 Sep 2019
Publication statusPublished - Dec 2019

Keywords

  • CASP, protein structure prediction, cryo-EM, X-ray crystallography, CASP, protein structure prediction