TY - JOUR
T1 - TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein-Barr virus
AU - Lautscham, GB
AU - Rickinson, Alan
AU - Blake, NW
PY - 2003/4/1
Y1 - 2003/4/1
N2 - For recognition by CD8(+) lymphocytes, peptides derived from cytosolically processed antigen need to access MHC class I molecules en route to the target cell surface. This normally requires peptide transport into the endoplasmic reticulum via the transporter associated with antigen presentation (TAP) complex. However, as recent work with Epstein-Barr virus illustrates, TAP-independent presentation pathways also exist and are growing in number. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
AB - For recognition by CD8(+) lymphocytes, peptides derived from cytosolically processed antigen need to access MHC class I molecules en route to the target cell surface. This normally requires peptide transport into the endoplasmic reticulum via the transporter associated with antigen presentation (TAP) complex. However, as recent work with Epstein-Barr virus illustrates, TAP-independent presentation pathways also exist and are growing in number. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=0037386520&partnerID=8YFLogxK
U2 - 10.1016/S1286-4579(03)00031-5
DO - 10.1016/S1286-4579(03)00031-5
M3 - Article
C2 - 12706442
SN - 1769-714X
VL - 5
SP - 291
EP - 299
JO - Microbes and Infection
JF - Microbes and Infection
IS - 4
ER -