Tailoring iridium luminescence and gold nanoparticle size for imaging of microvascular blood flow

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Tailoring iridium luminescence and gold nanoparticle size for imaging of microvascular blood flow. / Rogers, Nicola J; Jeffery, Hannah C; Claire, Sunil; Lewis, David J; Zikeli, Gerald; Hodges, Nikolas J; Egginton, Stuart; Nash, Gerard B; Pikramenou, Zoe.

In: Nanomedicine, Vol. 12, No. 22, 2017, p. 2726-2740.

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@article{546130ef136246c583d5b178121e8eca,
title = "Tailoring iridium luminescence and gold nanoparticle size for imaging of microvascular blood flow",
abstract = "AIM: Imaging of blood flow in narrow channels and close to vessel walls is important in cardiovascular research for understanding pathogenesis. Our aim was to provide novel nanoprobes with visible emission and long lifetimes as trackers of flow.MATERIALS & METHODS: Gold nanoparticles coated with an iridium complex were prepared. Luminescence imaging was used to monitor their flows in different hematocrit blood and in murine tissues.RESULTS: The velocities are independent of hematocrit level and the nanoparticles entering blood circulation can be clearly detected in vessels in lungs, mesentery and the skeletal muscle.CONCLUSION: The work introduces for the first time iridium-based yellow-green luminescence with nanoparticle size of 100 nm for visualizing and monitoring flows with much higher resolution than conventional alternatives.",
keywords = "blood flow, gold nanoparticles , imaging , luminescence , metal probes",
author = "Rogers, {Nicola J} and Jeffery, {Hannah C} and Sunil Claire and Lewis, {David J} and Gerald Zikeli and Hodges, {Nikolas J} and Stuart Egginton and Nash, {Gerard B} and Zoe Pikramenou",
year = "2017",
doi = "10.2217/nnm-2017-0211",
language = "English",
volume = "12",
pages = "2726--2740",
journal = "Nanomedicine",
issn = "1743-5889",
publisher = "Future Medicine",
number = "22",

}

RIS

TY - JOUR

T1 - Tailoring iridium luminescence and gold nanoparticle size for imaging of microvascular blood flow

AU - Rogers, Nicola J

AU - Jeffery, Hannah C

AU - Claire, Sunil

AU - Lewis, David J

AU - Zikeli, Gerald

AU - Hodges, Nikolas J

AU - Egginton, Stuart

AU - Nash, Gerard B

AU - Pikramenou, Zoe

PY - 2017

Y1 - 2017

N2 - AIM: Imaging of blood flow in narrow channels and close to vessel walls is important in cardiovascular research for understanding pathogenesis. Our aim was to provide novel nanoprobes with visible emission and long lifetimes as trackers of flow.MATERIALS & METHODS: Gold nanoparticles coated with an iridium complex were prepared. Luminescence imaging was used to monitor their flows in different hematocrit blood and in murine tissues.RESULTS: The velocities are independent of hematocrit level and the nanoparticles entering blood circulation can be clearly detected in vessels in lungs, mesentery and the skeletal muscle.CONCLUSION: The work introduces for the first time iridium-based yellow-green luminescence with nanoparticle size of 100 nm for visualizing and monitoring flows with much higher resolution than conventional alternatives.

AB - AIM: Imaging of blood flow in narrow channels and close to vessel walls is important in cardiovascular research for understanding pathogenesis. Our aim was to provide novel nanoprobes with visible emission and long lifetimes as trackers of flow.MATERIALS & METHODS: Gold nanoparticles coated with an iridium complex were prepared. Luminescence imaging was used to monitor their flows in different hematocrit blood and in murine tissues.RESULTS: The velocities are independent of hematocrit level and the nanoparticles entering blood circulation can be clearly detected in vessels in lungs, mesentery and the skeletal muscle.CONCLUSION: The work introduces for the first time iridium-based yellow-green luminescence with nanoparticle size of 100 nm for visualizing and monitoring flows with much higher resolution than conventional alternatives.

KW - blood flow

KW - gold nanoparticles

KW - imaging

KW - luminescence

KW - metal probes

U2 - 10.2217/nnm-2017-0211

DO - 10.2217/nnm-2017-0211

M3 - Article

C2 - 28960141

VL - 12

SP - 2726

EP - 2740

JO - Nanomedicine

JF - Nanomedicine

SN - 1743-5889

IS - 22

ER -