T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility

Research output: Contribution to journalArticlepeer-review

Authors

  • Michella Ghassibe-Sabbagh
  • Marc Haber
  • Angelique K. Salloum
  • Yasser Al-Sarraj
  • Yasmine Akle
  • And 7 others
  • Kamal Hirbli
  • Jihane Romanos
  • Francis Mouzaya
  • Dominique Gauguier
  • Daniel E. Platt
  • Hatem El-Shanti
  • Pierre A. Zalloua

Colleges, School and Institutes

External organisations

  • Shafallah Medical Genetics Center
  • Centre Hospitalier du Nord-CHN
  • University Medical Center, Rizk Hospital (UMC-RH)
  • Centre de Recherche des Cordeliers
  • IBM Research Division, T.J. Watson Research Center
  • University of Iowa Carver College of Medicine
  • Harvard School of Public Health
  • Lebanese American University

Abstract

Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10-9) and rs34872471 (OR = 1.35, P = 1.01 × 10-8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.

Details

Original languageEnglish
Article number7351
Number of pages9
JournalScientific Reports
Volume4
Publication statusPublished - 8 Dec 2014

ASJC Scopus subject areas