TY - JOUR
T1 - Systems biology
T2 - the elements and principles of life
AU - Westerhoff, Hans V
AU - Winder, Catherine
AU - Messiha, Hanan
AU - Simeonidis, Evangelos
AU - Adamczyk, Malgorzata
AU - Verma, Malkhey
AU - Bruggeman, Frank J
AU - Dunn, Warwick
PY - 2009/12/17
Y1 - 2009/12/17
N2 - Systems Biology has a mission that puts it at odds with traditional paradigms of physics and molecular biology, such as the simplicity requested by Occam's razor and minimum energy/maximal efficiency. By referring to biochemical experiments on control and regulation, and on flux balancing in yeast, we show that these paradigms are inapt. Systems Biology does not quite converge with biology either: Although it certainly requires accurate 'stamp collecting', it discovers quantitative laws. Systems Biology is a science of its own, discovering own fundamental principles, some of which we identify here.
AB - Systems Biology has a mission that puts it at odds with traditional paradigms of physics and molecular biology, such as the simplicity requested by Occam's razor and minimum energy/maximal efficiency. By referring to biochemical experiments on control and regulation, and on flux balancing in yeast, we show that these paradigms are inapt. Systems Biology does not quite converge with biology either: Although it certainly requires accurate 'stamp collecting', it discovers quantitative laws. Systems Biology is a science of its own, discovering own fundamental principles, some of which we identify here.
U2 - 10.1016/j.febslet.2009.11.018
DO - 10.1016/j.febslet.2009.11.018
M3 - Article
C2 - 19913018
SN - 1873-3468
VL - 583
SP - 3882
EP - 3890
JO - FEBS Letters
JF - FEBS Letters
IS - 24
ER -