Synthesis, properties and biomedical applications of hydrolytically degradable materials based on aliphatic polyesters and polycarbonates

R.P. Brannigan, A.P. Dove

Research output: Contribution to journalArticlepeer-review

141 Citations (Scopus)

Abstract

Polyester-based polymers represent excellent candidates in synthetic biodegradable and bioabsorbable materials for medical applications owing to their tailorable properties. The use of synthetic polyesters as biomaterials offers a unique control of morphology, mechanical properties and degradation profile through monomer selection, polymer composition (i.e. copolymer vs. homopolymer, stereocomplexation etc.) and molecular weight. Within this review, the synthetic routes, degradation modes and application of aliphatic polyester- and polycarbonate-based biomaterials are discussed.
Original languageEnglish
Pages (from-to)9-21
JournalBiomaterials Science
Volume5
DOIs
Publication statusPublished - 14 Nov 2016

Keywords

  • morphology
  • degradation profile
  • monomer selection
  • polymer composition
  • aliphatic
  • polycarbonate-based
  • polyester-based

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