Abstract
Ene cyclisation of a variety of 4-aza-1,7-dienes affords 3,4-disubstituted piperidines. In particular, cyclisation of diesters 14 and 20 catalysed by MeAlCl2 gives the corresponding trans 3,4-disubstituted piperidines with diastereomeric ratios of > 200:1. (c) 2005 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 6611-6615 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 39 |
DOIs | |
Publication status | Published - 26 Sept 2005 |
Keywords
- cyclisation
- piperidine
- ene