Synthesis and Self-Assembly of Amphiphilic Chiral Poly(amino acid) Star Polymers

Jared Skey; Helen Willcock; Mieke Lammens; Filip Du Prez; Rachel K. O'Reilly

doi:10.1021/ma101019g

Synthesis and Self-Assembly of Amphiphilic Chiral Poly(amino acid) Star Polymers

Jared Skey, Helen Willcock, Mieke Lammens, Filip Du Prez, Rachel K. O'Reilly

Chemistry

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Reversible addition−fragmentation chain transfer (RAFT) polymerization techniques were utilized to polymerize N-acryloyl-l-phenylalanine methyl ester (l-Phe-OMe) and tetrahydropyranyl acrylate to afford amphiphilic star polymers (with 4 and 6 arms). These copolymer stars have a chiral hydrophobic core domain and can undergo further solution self-assembly to form well-defined nanostructures, which have been characterized using DLS, TEM, and cryo-TEM analysis. The characterization and properties of these novel chiral assemblies and their potential in racemic resolution are reported.

Original language	English
Pages (from-to)	5949-5955
Journal	Macromolecules
Volume	43
Issue number	14
DOIs	https://doi.org/10.1021/ma101019g
Publication status	Published - 1 Jul 2010

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AB - Reversible addition−fragmentation chain transfer (RAFT) polymerization techniques were utilized to polymerize N-acryloyl-l-phenylalanine methyl ester (l-Phe-OMe) and tetrahydropyranyl acrylate to afford amphiphilic star polymers (with 4 and 6 arms). These copolymer stars have a chiral hydrophobic core domain and can undergo further solution self-assembly to form well-defined nanostructures, which have been characterized using DLS, TEM, and cryo-TEM analysis. The characterization and properties of these novel chiral assemblies and their potential in racemic resolution are reported.

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Synthesis and Self-Assembly of Amphiphilic Chiral Poly(amino acid) Star Polymers

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