Synthesis and cytotoxicity of dinuclear complexes containing ruthenium(ii) bipyridyl units linked by a bis(pyridylimine) ligand

Research output: Contribution to journalArticle

Authors

  • U McDonnell
  • JMCA Kerchoffs
  • RPM Castineiras
  • MR Hicks
  • A Rodger

Colleges, School and Institutes

Abstract

Enantiopure dinuclear ruthenium polypyridyl complexes of the form [Ru-2(LL)(4)L-1](PF6)(4) (LL = 2,2'-bipyridine (bpy) or 1,10-phenanthroline (phen); L-1 = C25H20N4 a bis(pyridylimine) ligand containing a diphenylmethane spacer) have been synthesized using the chiral building blocks cis-[Ru(bpy)(2)(py)(2)](2+) and cis-[Ru(phen)(2)(py)(2)](2+). These dinuclear ruthenium complexes have been characterised using NMR, mass spectrometry, UV-visible absorbance, circular dichroism and linear dichroism. The compounds exhibit good photo and thermal stability. The extinction coefficient for the bpy complex at 478 nm is epsilon(478) = 15 700 mol(-1) cm(-1) dm(3) and for the phen complex is epsilon(478) = 24900 mol(-1) cm(-1) dm(3). Both complexes have their longest wavelength (metal to ligand charge transfer) transition predominantly x/y (short axis)-polarised while the transitions at shorter wavelength are a mixture of x/y and z-polarisations, similar to both the copper helicate and iron triple helicate studied previously. Cytotoxicity studies reveal that the compounds are dramatically less active against cancer cell lines than the recently reported supramolecular cylinders prepared from the same bis(pyridylimine) ligand.

Details

Original languageEnglish
Pages (from-to)667
Number of pages1
JournalDalton Transactions
Volume2008
Issue number5
Publication statusPublished - 1 Jan 2008