Synthesis and biological study of acridine-based imidazolium salts

Research output: Contribution to journalArticlepeer-review

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Synthesis and biological study of acridine-based imidazolium salts. / Sharhan, Olla ; Heidelberg, Thorsten ; Hashim, Najiahah Mohd ; Salman, Abbas Abdulameer ; Ali, Hapipah Mohd ; Jayash, Soher.

In: RSC Advances, No. 68, 38995, 20.11.2018, p. 38995–39004.

Research output: Contribution to journalArticlepeer-review

Harvard

Sharhan, O, Heidelberg, T, Hashim, NM, Salman, AA, Ali, HM & Jayash, S 2018, 'Synthesis and biological study of acridine-based imidazolium salts', RSC Advances, no. 68, 38995, pp. 38995–39004. https://doi.org/10.1039/c8ra08138g

APA

Sharhan, O., Heidelberg, T., Hashim, N. M., Salman, A. A., Ali, H. M., & Jayash, S. (2018). Synthesis and biological study of acridine-based imidazolium salts. RSC Advances, (68), 38995–39004. [38995]. https://doi.org/10.1039/c8ra08138g

Vancouver

Sharhan O, Heidelberg T, Hashim NM, Salman AA, Ali HM, Jayash S. Synthesis and biological study of acridine-based imidazolium salts. RSC Advances. 2018 Nov 20;(68):38995–39004. 38995. https://doi.org/10.1039/c8ra08138g

Author

Sharhan, Olla ; Heidelberg, Thorsten ; Hashim, Najiahah Mohd ; Salman, Abbas Abdulameer ; Ali, Hapipah Mohd ; Jayash, Soher. / Synthesis and biological study of acridine-based imidazolium salts. In: RSC Advances. 2018 ; No. 68. pp. 38995–39004.

Bibtex

@article{b1be98754b6a46b8ac2667ae96d5867b,
title = "Synthesis and biological study of acridine-based imidazolium salts",
abstract = "A new series of acridine based imidazolium salts was synthesized and evaluated for in vitro cytotoxicity against human cancer cell lines by an MTT assay. The synthesis applied a coupling of imidazoles with 9-chloroacridines, which originated from an Ullmann condensation of a 2-chloro-benzoic acid with an aniline. The target compounds were obtained in high yields. The DPPH assay indicated considerable antioxidant activity for target compounds with simple and short alkyl chains on the imidazole, while increasing chain length and the introduction of an additional π-electron system in most cases reduced the activity. All compounds exhibited low biotoxicity against non-cancerous cell lines, whereas a few compounds showed promising anticancer activity. Unlike for the reference drugs Tamoxifen and Paclitaxel, the anticancer activity of acridine imidazolium ions is specific for only selected cancer types. Reasonable fluorescent behaviour of the products provide potential for visualization of the distribution of active drugs in tissue.",
author = "Olla Sharhan and Thorsten Heidelberg and Hashim, {Najiahah Mohd} and Salman, {Abbas Abdulameer} and Ali, {Hapipah Mohd} and Soher Jayash",
year = "2018",
month = nov,
day = "20",
doi = "10.1039/c8ra08138g",
language = "English",
pages = "38995–39004",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "68",

}

RIS

TY - JOUR

T1 - Synthesis and biological study of acridine-based imidazolium salts

AU - Sharhan, Olla

AU - Heidelberg, Thorsten

AU - Hashim, Najiahah Mohd

AU - Salman, Abbas Abdulameer

AU - Ali, Hapipah Mohd

AU - Jayash, Soher

PY - 2018/11/20

Y1 - 2018/11/20

N2 - A new series of acridine based imidazolium salts was synthesized and evaluated for in vitro cytotoxicity against human cancer cell lines by an MTT assay. The synthesis applied a coupling of imidazoles with 9-chloroacridines, which originated from an Ullmann condensation of a 2-chloro-benzoic acid with an aniline. The target compounds were obtained in high yields. The DPPH assay indicated considerable antioxidant activity for target compounds with simple and short alkyl chains on the imidazole, while increasing chain length and the introduction of an additional π-electron system in most cases reduced the activity. All compounds exhibited low biotoxicity against non-cancerous cell lines, whereas a few compounds showed promising anticancer activity. Unlike for the reference drugs Tamoxifen and Paclitaxel, the anticancer activity of acridine imidazolium ions is specific for only selected cancer types. Reasonable fluorescent behaviour of the products provide potential for visualization of the distribution of active drugs in tissue.

AB - A new series of acridine based imidazolium salts was synthesized and evaluated for in vitro cytotoxicity against human cancer cell lines by an MTT assay. The synthesis applied a coupling of imidazoles with 9-chloroacridines, which originated from an Ullmann condensation of a 2-chloro-benzoic acid with an aniline. The target compounds were obtained in high yields. The DPPH assay indicated considerable antioxidant activity for target compounds with simple and short alkyl chains on the imidazole, while increasing chain length and the introduction of an additional π-electron system in most cases reduced the activity. All compounds exhibited low biotoxicity against non-cancerous cell lines, whereas a few compounds showed promising anticancer activity. Unlike for the reference drugs Tamoxifen and Paclitaxel, the anticancer activity of acridine imidazolium ions is specific for only selected cancer types. Reasonable fluorescent behaviour of the products provide potential for visualization of the distribution of active drugs in tissue.

U2 - 10.1039/c8ra08138g

DO - 10.1039/c8ra08138g

M3 - Article

SP - 38995

EP - 39004

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

IS - 68

M1 - 38995

ER -