TY - JOUR
T1 - Synthesis and applications of superacids. 1,1,2,2-Tetrafluoroethanesulfonic acid, supported on silica
AU - Harmer, Mark A.
AU - Junk, Christopher
AU - Rostovtsev, Vsevolod
AU - Carcani, Liane G.
AU - Vickery, Jemma
AU - Schnepp, Zoe
PY - 2007/1/11
Y1 - 2007/1/11
N2 - In this paper we focus on the synthesis and use of superacids, in particular 1,1,2,2-tetrafluoroethanesulfonic acid (TFESA), and describe how these can be optimized for reactions of key industrial importance. One area of considerable interest is the field of superacid catalysis and, specifically, the development of safer and more cost-effective acid catalysts. We report a new simplified route for preparation of these acids, making these more readily available and opening up a large number of opportunities. Partially fluorinated superacids offer several advantages over the acids commonly used in catalysis (sulfuric, hydrofluoric acid and aluminium chloride): lower loadings, lower reaction temperatures (leading to increased selectivity), fewer by-products, shorter reaction times and higher throughput. TFESA and its longer chain analogs are much less volatile than triflic acid (CF3SO3H). We tested these superacids in several processes (aromatic alkylation, acylation of arenes, isomerization, oligomerization and the Fries rearrangement). These materials are excellent acid catalysts, comparable to triflic acid, and yet easier to handle. We have also prepared supported versions of these catalysts and introduced the ability to recycle.
AB - In this paper we focus on the synthesis and use of superacids, in particular 1,1,2,2-tetrafluoroethanesulfonic acid (TFESA), and describe how these can be optimized for reactions of key industrial importance. One area of considerable interest is the field of superacid catalysis and, specifically, the development of safer and more cost-effective acid catalysts. We report a new simplified route for preparation of these acids, making these more readily available and opening up a large number of opportunities. Partially fluorinated superacids offer several advantages over the acids commonly used in catalysis (sulfuric, hydrofluoric acid and aluminium chloride): lower loadings, lower reaction temperatures (leading to increased selectivity), fewer by-products, shorter reaction times and higher throughput. TFESA and its longer chain analogs are much less volatile than triflic acid (CF3SO3H). We tested these superacids in several processes (aromatic alkylation, acylation of arenes, isomerization, oligomerization and the Fries rearrangement). These materials are excellent acid catalysts, comparable to triflic acid, and yet easier to handle. We have also prepared supported versions of these catalysts and introduced the ability to recycle.
UR - http://www.scopus.com/inward/record.url?scp=33845978445&partnerID=8YFLogxK
U2 - 10.1039/b607428f
DO - 10.1039/b607428f
M3 - Article
AN - SCOPUS:33845978445
SN - 1463-9262
VL - 9
SP - 30
EP - 37
JO - Green Chemistry
JF - Green Chemistry
IS - 1
ER -