Syncope in hypertrophic cardiomyopathy: mechanisms and consequences for treatment

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Colleges, School and Institutes

Abstract

Hypertrophic cardiomyopathy (HCM) is an inherited disease with marked phenotypic variability that includes the extent of hypertrophy, the presence and severity of symptoms, and the natural history of the disease. Symptoms of impaired consciousness (syncope and pre-syncope) occur in approximately 15-25% of patients with hypertrophic cardiomyopathy (HCM). In young patients a history of recurrent syncope is associated with an increased risk of sudden death. Detailed investigations identify a probable mechanism in a minority of these, usually paroxysmal atrial fibrillation or ventricular tachycardia. In the majority, however, no likely mechanism is found despite extensive investigation. Although this may be the case, it is still of vital importance to exclude potentially treatable causes of syncope.

Details

Original languageEnglish
Pages (from-to)817-22
Number of pages6
JournalEuropace
Volume9
Issue number9
Early online date23 May 2007
Publication statusPublished - 17 Jul 2007