Symptoms of depression and cardiovascular reactions to acute psychological stress: Evidence from a population study

Research output: Contribution to journalArticlepeer-review

Authors

Colleges, School and Institutes

External organisations

  • MRC/CSO Social and Public Health Sciences Unit

Abstract

Depression and exaggerated cardiovascular reactivity are considered risk factors for cardiovascular disease, possibly as a result of common antecedents, such as altered autonomic nervous system function. We examined the association between depressive symptomatology and cardiovascular reactions to psychological stress in 1608 adults (875 women) comprising 3 distinct age cohorts: 24-, 44-, and 63-year olds. Depression was assessed using the Hospital Anxiety and Depression Scale. Blood pressure and heart rate were measured at baseline and during the paced auditory serial arithmetic test. Depression scores were negatively associated with systolic blood pressure and heart rate reactions, after adjustment for likely confounders such as sex, cohort, occupational status, body mass index, stress task performance score, baseline cardiovascular activity, antidepressant, and antihypertensive medication. The direction of association was opposite to that which would be expected if excessive reactivity were to mediate the association between depression and cardiovascular disease outcomes or if they shared common antecedents.

Details

Original languageEnglish
Pages (from-to)68-74
Number of pages7
JournalBiological Psychology
Volume75
Issue number1
Early online date29 Dec 2006
Publication statusPublished - 1 Apr 2007

Keywords

  • psychological stress, heart rate, blood pressure, depression