Swelling of high acyl gellan gum hydrogel: characterization of network strengthening and slower release

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Colleges, School and Institutes

Abstract

This study examined the mechanism of swelling for high acyl (HA) gellan gum and the impacts on the hydrogel mechanical properties and the release of a model drug (glucose). Controlling the material properties and the release of entrapped drugs during use in aqueous environments, such as the stomach or bodily fluids, are crucial in designing functional applications. Swelling of HA gellan gum was controlled by varying the osmotic environment with salts and solvents, and effects on the gel network were characterized by uniaxial compression tests, DSC, and rheology. Low ionic strength solutions caused the greatest degree of swelling (up to 400 %) and corresponded to a more brittle gel with a greater modulus and greater network enthalpy. Swelling slowed the release of glucose by decreasing the diffusion flux. The osmotic environment was found to produce different functional properties, and it is crucial to consider these changes in the design of formulations.

Bibliographic note

Funding Information: This research was partially funded by the Engineering and Physical Sciences Research Council [grant number EP/K030957/1 ], the EPSRC Centre for Innovative Manufacturing in Food . Publisher Copyright: © 2021 Elsevier Ltd

Details

Original languageEnglish
Article number117758
Number of pages9
JournalCarbohydrate Polymers
Volume259
Early online date6 Feb 2021
Publication statusPublished - 1 May 2021

Keywords

  • Drug release, Gellan gum, Gellan hydrogel, Superabsorbent hydrogel, Swelling, Tissue scaffold