Surveillance of HPV-Positive Head and Neck Squamous Cell Carcinoma with Circulating and Salivary DNA Biomarkers

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Surveillance of HPV-Positive Head and Neck Squamous Cell Carcinoma with Circulating and Salivary DNA Biomarkers. / Borsetto, Daniele; Cheng, Jordan; Payne, Karl; Nankivell, Paul; Batis, Nikolas; Rao, Kanishka; Bhide, Shreerang; Li, Feng; Kim, Yong; Mehanna, Hisham; Wong, David.

In: Critical Reviews in Oncogenesis, Vol. 23, No. 3-4, 31.07.2018, p. 235-245.

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Borsetto, Daniele ; Cheng, Jordan ; Payne, Karl ; Nankivell, Paul ; Batis, Nikolas ; Rao, Kanishka ; Bhide, Shreerang ; Li, Feng ; Kim, Yong ; Mehanna, Hisham ; Wong, David. / Surveillance of HPV-Positive Head and Neck Squamous Cell Carcinoma with Circulating and Salivary DNA Biomarkers. In: Critical Reviews in Oncogenesis. 2018 ; Vol. 23, No. 3-4. pp. 235-245.

Bibtex

@article{77ae4d2c4d274a64a7257d4951a3cc62,
title = "Surveillance of HPV-Positive Head and Neck Squamous Cell Carcinoma with Circulating and Salivary DNA Biomarkers",
abstract = "Head and neck squamous cell carcinoma (HNSCC) manifests in the mucosal epithelial lining of the oral cavity, oropharynx, hypopharynx, nasopharynx or larynx and has a tremendous disease burden worldwide. Smoking and alcohol consumption were once major risk factors, but HPV-associated infection has emerged as the major contributor to HNSCC occurrence in developed countries. Circulating biomarker evaluations in biofluids, also known as liquid biopsy, are an attractive alternative for cancer screening as they are minimally invasive, potentially low cost, and easily repeatable on a serial basis. This review summarizes the current knowledge and potential of assessing circulating blood and salivary HPV DNA and HPV antibodies for the surveillance of HPV-positive HNSCC. Additionally, the biological underpinnings of the presence and relevance of circulating HPV DNA is discussed.",
keywords = "head and neck squamous cell carcinoma, liquid biopsy, circulating tumor DNA, exosomes",
author = "Daniele Borsetto and Jordan Cheng and Karl Payne and Paul Nankivell and Nikolas Batis and Kanishka Rao and Shreerang Bhide and Feng Li and Yong Kim and Hisham Mehanna and David Wong",
year = "2018",
month = jul
day = "31",
doi = "10.1615/CritRevOncog.2018027689",
language = "English",
volume = "23",
pages = "235--245",
journal = "Critical Reviews in Oncogenesis",
issn = "0893-9675",
publisher = "Begell House",
number = "3-4",

}

RIS

TY - JOUR

T1 - Surveillance of HPV-Positive Head and Neck Squamous Cell Carcinoma with Circulating and Salivary DNA Biomarkers

AU - Borsetto, Daniele

AU - Cheng, Jordan

AU - Payne, Karl

AU - Nankivell, Paul

AU - Batis, Nikolas

AU - Rao, Kanishka

AU - Bhide, Shreerang

AU - Li, Feng

AU - Kim, Yong

AU - Mehanna, Hisham

AU - Wong, David

PY - 2018/7/31

Y1 - 2018/7/31

N2 - Head and neck squamous cell carcinoma (HNSCC) manifests in the mucosal epithelial lining of the oral cavity, oropharynx, hypopharynx, nasopharynx or larynx and has a tremendous disease burden worldwide. Smoking and alcohol consumption were once major risk factors, but HPV-associated infection has emerged as the major contributor to HNSCC occurrence in developed countries. Circulating biomarker evaluations in biofluids, also known as liquid biopsy, are an attractive alternative for cancer screening as they are minimally invasive, potentially low cost, and easily repeatable on a serial basis. This review summarizes the current knowledge and potential of assessing circulating blood and salivary HPV DNA and HPV antibodies for the surveillance of HPV-positive HNSCC. Additionally, the biological underpinnings of the presence and relevance of circulating HPV DNA is discussed.

AB - Head and neck squamous cell carcinoma (HNSCC) manifests in the mucosal epithelial lining of the oral cavity, oropharynx, hypopharynx, nasopharynx or larynx and has a tremendous disease burden worldwide. Smoking and alcohol consumption were once major risk factors, but HPV-associated infection has emerged as the major contributor to HNSCC occurrence in developed countries. Circulating biomarker evaluations in biofluids, also known as liquid biopsy, are an attractive alternative for cancer screening as they are minimally invasive, potentially low cost, and easily repeatable on a serial basis. This review summarizes the current knowledge and potential of assessing circulating blood and salivary HPV DNA and HPV antibodies for the surveillance of HPV-positive HNSCC. Additionally, the biological underpinnings of the presence and relevance of circulating HPV DNA is discussed.

KW - head and neck squamous cell carcinoma

KW - liquid biopsy

KW - circulating tumor DNA

KW - exosomes

U2 - 10.1615/CritRevOncog.2018027689

DO - 10.1615/CritRevOncog.2018027689

M3 - Article

C2 - 30311577

VL - 23

SP - 235

EP - 245

JO - Critical Reviews in Oncogenesis

JF - Critical Reviews in Oncogenesis

SN - 0893-9675

IS - 3-4

ER -