Surgery in the era of the 'omics revolution

Research output: Contribution to journalArticlepeer-review

Authors

Colleges, School and Institutes

Abstract

Background
Surgery is entering a new phase with the revolution in genomic technology. Cheap, mass access to next-generation sequencing is now allowing the analysis of entire human genomes at the DNA and RNA level. These data sets are being used increasingly to identify the molecular differences that underlie common surgical diseases, and enable them to be stratified for patient benefit.

Methods
This article reviews the recent developments in the molecular biology of colorectal, oesophagogastric and breast cancer.

Results
The review specifically covers developments in genetic predisposition, next-generation sequencing studies, biomarkers for stratification, prognosis and treatment, and other 'omics technologies such as metabolomics and proteomics.

Conclusion
There are unique opportunities over the next decade to change the management of surgical disease radically, using these technologies. The directions that this may take are highlighted, including future advances such as the 100 000 Genomes Project.

Details

Original languageEnglish
Pages (from-to)e29-e40
JournalBritish Journal of Surgery
Volume102
Issue number2
Publication statusPublished - 27 Jan 2015