Surface functionalization of graphene-based materials: biological behavior, toxicology, and safe-by-design aspects

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Surface functionalization of graphene-based materials : biological behavior, toxicology, and safe-by-design aspects. / Guo, Zhiling; Chakraborty, Swaroop; Monikh, Fazel Abdolahpur; Varsou, Dimitra-Danai; Chetwynd, Andrew J; Afantitis, Antreas; Lynch, Iseult; Zhang, Peng.

In: Advanced Biology, Vol. 2021, 2100637, 20.07.2021.

Research output: Contribution to journalReview articlepeer-review

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@article{64a3131337e447769aacc8fea126cf3b,
title = "Surface functionalization of graphene-based materials: biological behavior, toxicology, and safe-by-design aspects",
abstract = "The increasing exploitation of graphene-based materials (GBMs) is driven by their unique properties and structures, which ignite the imagination of scientists and engineers. At the same time, the very properties that make them so useful for applications lead to growing concerns regarding their potential impacts on human health and the environment. Since GBMs are inert to reaction, various attempts of surface functionalization are made to make them reactive. Herein, surface functionalization of GBMs, including those intentionally designed for specific applications, as well as those unintentionally acquired (e.g., protein corona formation) from the environment and biota, are reviewed through the lenses of nanotoxicity and design of safe materials (safe-by-design). Uptake and toxicity of functionalized GBMs and the underlying mechanisms are discussed and linked with the surface functionalization. Computational tools that can predict the interaction of GBMs behavior with their toxicity are discussed. A concise framing of current knowledge and key features of GBMs to be controlled for safe and sustainable applications are provided for the community.",
author = "Zhiling Guo and Swaroop Chakraborty and Monikh, {Fazel Abdolahpur} and Dimitra-Danai Varsou and Chetwynd, {Andrew J} and Antreas Afantitis and Iseult Lynch and Peng Zhang",
note = "Acknowledgement: This work was primarily supported by the EU H2020 project NanoSolveIT (Grant Agreement No. 814572), RiskGone (Grant Agreement No. 814425), and NanoCommons (Grant Agreement No. 731032). Additional support from the UoB Institute for Global Innovation Environmental Pollution Solutions theme is acknowledged. {\textcopyright} 2021 The Authors. Advanced Biology published by Wiley-VCH GmbH.",
year = "2021",
month = jul,
day = "20",
doi = "10.1002/adbi.202100637",
language = "English",
volume = "2021",
journal = "Advanced Biology",
issn = "2701-0198",
publisher = "Wiley",

}

RIS

TY - JOUR

T1 - Surface functionalization of graphene-based materials

T2 - biological behavior, toxicology, and safe-by-design aspects

AU - Guo, Zhiling

AU - Chakraborty, Swaroop

AU - Monikh, Fazel Abdolahpur

AU - Varsou, Dimitra-Danai

AU - Chetwynd, Andrew J

AU - Afantitis, Antreas

AU - Lynch, Iseult

AU - Zhang, Peng

N1 - Acknowledgement: This work was primarily supported by the EU H2020 project NanoSolveIT (Grant Agreement No. 814572), RiskGone (Grant Agreement No. 814425), and NanoCommons (Grant Agreement No. 731032). Additional support from the UoB Institute for Global Innovation Environmental Pollution Solutions theme is acknowledged. © 2021 The Authors. Advanced Biology published by Wiley-VCH GmbH.

PY - 2021/7/20

Y1 - 2021/7/20

N2 - The increasing exploitation of graphene-based materials (GBMs) is driven by their unique properties and structures, which ignite the imagination of scientists and engineers. At the same time, the very properties that make them so useful for applications lead to growing concerns regarding their potential impacts on human health and the environment. Since GBMs are inert to reaction, various attempts of surface functionalization are made to make them reactive. Herein, surface functionalization of GBMs, including those intentionally designed for specific applications, as well as those unintentionally acquired (e.g., protein corona formation) from the environment and biota, are reviewed through the lenses of nanotoxicity and design of safe materials (safe-by-design). Uptake and toxicity of functionalized GBMs and the underlying mechanisms are discussed and linked with the surface functionalization. Computational tools that can predict the interaction of GBMs behavior with their toxicity are discussed. A concise framing of current knowledge and key features of GBMs to be controlled for safe and sustainable applications are provided for the community.

AB - The increasing exploitation of graphene-based materials (GBMs) is driven by their unique properties and structures, which ignite the imagination of scientists and engineers. At the same time, the very properties that make them so useful for applications lead to growing concerns regarding their potential impacts on human health and the environment. Since GBMs are inert to reaction, various attempts of surface functionalization are made to make them reactive. Herein, surface functionalization of GBMs, including those intentionally designed for specific applications, as well as those unintentionally acquired (e.g., protein corona formation) from the environment and biota, are reviewed through the lenses of nanotoxicity and design of safe materials (safe-by-design). Uptake and toxicity of functionalized GBMs and the underlying mechanisms are discussed and linked with the surface functionalization. Computational tools that can predict the interaction of GBMs behavior with their toxicity are discussed. A concise framing of current knowledge and key features of GBMs to be controlled for safe and sustainable applications are provided for the community.

U2 - 10.1002/adbi.202100637

DO - 10.1002/adbi.202100637

M3 - Review article

C2 - 34288601

VL - 2021

JO - Advanced Biology

JF - Advanced Biology

SN - 2701-0198

M1 - 2100637

ER -