Superior mesenteric and renal flow patterns during intra-aortic counterpulsation

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Superior mesenteric and renal flow patterns during intra-aortic counterpulsation. / Johnson, Daniel M.; Lozekoot, Pieter; Jong, Monique de; Parise, Orlando; Makhoul, Maged; Matteucci, Francesco; Lucà, Fabiana; Maessen, Jos G.; Gelsomino, Sandro.

In: Experimental Physiology, Vol. 104, No. 5, 01.05.2019, p. 643-653.

Research output: Contribution to journalArticlepeer-review

Harvard

Johnson, DM, Lozekoot, P, Jong, MD, Parise, O, Makhoul, M, Matteucci, F, Lucà, F, Maessen, JG & Gelsomino, S 2019, 'Superior mesenteric and renal flow patterns during intra-aortic counterpulsation', Experimental Physiology, vol. 104, no. 5, pp. 643-653. https://doi.org/10.1113/EP086810

APA

Johnson, D. M., Lozekoot, P., Jong, M. D., Parise, O., Makhoul, M., Matteucci, F., Lucà, F., Maessen, J. G., & Gelsomino, S. (2019). Superior mesenteric and renal flow patterns during intra-aortic counterpulsation. Experimental Physiology, 104(5), 643-653. https://doi.org/10.1113/EP086810

Vancouver

Author

Johnson, Daniel M. ; Lozekoot, Pieter ; Jong, Monique de ; Parise, Orlando ; Makhoul, Maged ; Matteucci, Francesco ; Lucà, Fabiana ; Maessen, Jos G. ; Gelsomino, Sandro. / Superior mesenteric and renal flow patterns during intra-aortic counterpulsation. In: Experimental Physiology. 2019 ; Vol. 104, No. 5. pp. 643-653.

Bibtex

@article{69b4eaa98e994a88bbb4498fe82649e5,
title = "Superior mesenteric and renal flow patterns during intra-aortic counterpulsation",
abstract = "New Findings: What is the central question of this study? Visceral ischaemia is one of the most feared complications during use of an intra-aortic balloon pump. Using an animal model, we measured the flows at the abdominal level directly and examined flow patterns to enable investigation of flow patterns during the use of the intra-aortic balloon pump. What is the main finding and its importance? We show that there is a significant balloon-related reduction in superior mesenteric flow in both early and mid-diastole. Abstract: A number of previous studies have shown that blood flow in the visceral arteries is altered during intra-aortic balloon pump (IABP) treatment. We used a porcine model to analyse the pattern of blood flow into the visceral arteries during IABP use. For this purpose, we measured the superior mesenteric, right renal and left renal flows before and during IABP support, using surgically placed flowmeters surrounding these visceral arteries. The superior mesenteric flow significantly decreased in early diastole (P < 0.001) and in mid-diastole (P = 0.003 versus early diastole), whereas in late diastole it increased again (P < 0.001 versus mid-diastole). During systole, the flow was not significantly increased compared with late diastole (P = 0.51), but it was significantly lower than at baseline (both P < 0.001). Flows did not differ between right and left kidneys. Perfusion of either kidney did not change significantly in early diastole (P > 0.05), whereas it decreased significantly in mid-diastole (P < 0.001), rising dramatically in late diastole (P < 0.001) and with an additional slight increase in systole (P = 0.054). This study provides important insights into abdominal flows during intra-aortic pump counterpulsation. Furthermore, it supports the need to rethink the balloon design to avoid visceral ischaemia during circulatory assistance.",
keywords = "flow, intra-aortic balloon pump, perfusion",
author = "Johnson, {Daniel M.} and Pieter Lozekoot and Jong, {Monique de} and Orlando Parise and Maged Makhoul and Francesco Matteucci and Fabiana Luc{\`a} and Maessen, {Jos G.} and Sandro Gelsomino",
year = "2019",
month = may,
day = "1",
doi = "10.1113/EP086810",
language = "English",
volume = "104",
pages = "643--653",
journal = "Experimental Physiology",
issn = "0958-0670",
publisher = "Wiley",
number = "5",

}

RIS

TY - JOUR

T1 - Superior mesenteric and renal flow patterns during intra-aortic counterpulsation

AU - Johnson, Daniel M.

AU - Lozekoot, Pieter

AU - Jong, Monique de

AU - Parise, Orlando

AU - Makhoul, Maged

AU - Matteucci, Francesco

AU - Lucà, Fabiana

AU - Maessen, Jos G.

AU - Gelsomino, Sandro

PY - 2019/5/1

Y1 - 2019/5/1

N2 - New Findings: What is the central question of this study? Visceral ischaemia is one of the most feared complications during use of an intra-aortic balloon pump. Using an animal model, we measured the flows at the abdominal level directly and examined flow patterns to enable investigation of flow patterns during the use of the intra-aortic balloon pump. What is the main finding and its importance? We show that there is a significant balloon-related reduction in superior mesenteric flow in both early and mid-diastole. Abstract: A number of previous studies have shown that blood flow in the visceral arteries is altered during intra-aortic balloon pump (IABP) treatment. We used a porcine model to analyse the pattern of blood flow into the visceral arteries during IABP use. For this purpose, we measured the superior mesenteric, right renal and left renal flows before and during IABP support, using surgically placed flowmeters surrounding these visceral arteries. The superior mesenteric flow significantly decreased in early diastole (P < 0.001) and in mid-diastole (P = 0.003 versus early diastole), whereas in late diastole it increased again (P < 0.001 versus mid-diastole). During systole, the flow was not significantly increased compared with late diastole (P = 0.51), but it was significantly lower than at baseline (both P < 0.001). Flows did not differ between right and left kidneys. Perfusion of either kidney did not change significantly in early diastole (P > 0.05), whereas it decreased significantly in mid-diastole (P < 0.001), rising dramatically in late diastole (P < 0.001) and with an additional slight increase in systole (P = 0.054). This study provides important insights into abdominal flows during intra-aortic pump counterpulsation. Furthermore, it supports the need to rethink the balloon design to avoid visceral ischaemia during circulatory assistance.

AB - New Findings: What is the central question of this study? Visceral ischaemia is one of the most feared complications during use of an intra-aortic balloon pump. Using an animal model, we measured the flows at the abdominal level directly and examined flow patterns to enable investigation of flow patterns during the use of the intra-aortic balloon pump. What is the main finding and its importance? We show that there is a significant balloon-related reduction in superior mesenteric flow in both early and mid-diastole. Abstract: A number of previous studies have shown that blood flow in the visceral arteries is altered during intra-aortic balloon pump (IABP) treatment. We used a porcine model to analyse the pattern of blood flow into the visceral arteries during IABP use. For this purpose, we measured the superior mesenteric, right renal and left renal flows before and during IABP support, using surgically placed flowmeters surrounding these visceral arteries. The superior mesenteric flow significantly decreased in early diastole (P < 0.001) and in mid-diastole (P = 0.003 versus early diastole), whereas in late diastole it increased again (P < 0.001 versus mid-diastole). During systole, the flow was not significantly increased compared with late diastole (P = 0.51), but it was significantly lower than at baseline (both P < 0.001). Flows did not differ between right and left kidneys. Perfusion of either kidney did not change significantly in early diastole (P > 0.05), whereas it decreased significantly in mid-diastole (P < 0.001), rising dramatically in late diastole (P < 0.001) and with an additional slight increase in systole (P = 0.054). This study provides important insights into abdominal flows during intra-aortic pump counterpulsation. Furthermore, it supports the need to rethink the balloon design to avoid visceral ischaemia during circulatory assistance.

KW - flow

KW - intra-aortic balloon pump

KW - perfusion

UR - https://doi.org/10.1113/EP086810

U2 - 10.1113/EP086810

DO - 10.1113/EP086810

M3 - Article

VL - 104

SP - 643

EP - 653

JO - Experimental Physiology

JF - Experimental Physiology

SN - 0958-0670

IS - 5

ER -