Abstract
The cytosolic sulfotransferase enzymes (SULT isoforms) utilise PAPS (3'-phosphoadenosine-5'-phosphosulfate) as co-factor to transfer sulfonate groups onto a wide range of substrates. SULT1A3 has catecholamines such as dopamine as substrates while SULT 1E1 sulfonates oestrogens. SULT 1A1 sulfonates phenols and also oestrogens at a higher K-m than SULT 1E1. SULT 2A1 mainly sulfonates DHEA and some steroids, with hydroxy derivatives of polycyclic aromatic hydrocarbons. Studies on these isoforms with a range of environmental chemicals and dietary components have shown that SULT 1A1 is significantly inhibited by flavonoids; all flavones and flavonols with a 3',4'-dihydroxy motif had an IC50 of
Original language | English |
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Pages (from-to) | 269-275 |
Number of pages | 7 |
Journal | Current Drug Metabolism |
Volume | 9 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 May 2008 |
Keywords
- phthalates
- phenols
- inhibition
- sufotransferase
- flavonoids