Sulfenyl Ynamides in Gold Catalysis: Synthesis of Oxo‐functionalised 4‐aminoimidazolyl Fused Compounds by Intermolecular Annulation Reactions

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@article{f4c48dd0124f497196a500c77b2a129a,
title = "Sulfenyl Ynamides in Gold Catalysis: Synthesis of Oxo‐functionalised 4‐aminoimidazolyl Fused Compounds by Intermolecular Annulation Reactions",
abstract = "Functionalised N ‐heterocyclic pyridinium N ‐aminides have been designed and synthesised to evaluate a nitrenoid‐based annulation strategy into imidazole‐fused oxo‐substituted frameworks of importance to medicinal and agrochemical discovery programmes. Sulfenyl substituted ynamides were identified as privileged reactants affording productive gold‐catalysed annulation reactions with these and other nitrenoids. This annulation method provides selective and efficient access into geminally amino‐sulfenyl substituted nitrogen heterocycles under mild reaction conditions.",
author = "Arce, {Elsa M.} and Lamont, {Scott G.} and Davies, {Paul W.}",
year = "2020",
month = mar,
day = "24",
doi = "10.1002/adsc.202000134",
language = "English",
journal = "Advanced Synthesis & Catalysis",
issn = "1615-4169",
publisher = "Wiley-VCH Verlag",

}

RIS

TY - JOUR

T1 - Sulfenyl Ynamides in Gold Catalysis: Synthesis of Oxo‐functionalised 4‐aminoimidazolyl Fused Compounds by Intermolecular Annulation Reactions

AU - Arce, Elsa M.

AU - Lamont, Scott G.

AU - Davies, Paul W.

PY - 2020/3/24

Y1 - 2020/3/24

N2 - Functionalised N ‐heterocyclic pyridinium N ‐aminides have been designed and synthesised to evaluate a nitrenoid‐based annulation strategy into imidazole‐fused oxo‐substituted frameworks of importance to medicinal and agrochemical discovery programmes. Sulfenyl substituted ynamides were identified as privileged reactants affording productive gold‐catalysed annulation reactions with these and other nitrenoids. This annulation method provides selective and efficient access into geminally amino‐sulfenyl substituted nitrogen heterocycles under mild reaction conditions.

AB - Functionalised N ‐heterocyclic pyridinium N ‐aminides have been designed and synthesised to evaluate a nitrenoid‐based annulation strategy into imidazole‐fused oxo‐substituted frameworks of importance to medicinal and agrochemical discovery programmes. Sulfenyl substituted ynamides were identified as privileged reactants affording productive gold‐catalysed annulation reactions with these and other nitrenoids. This annulation method provides selective and efficient access into geminally amino‐sulfenyl substituted nitrogen heterocycles under mild reaction conditions.

U2 - 10.1002/adsc.202000134

DO - 10.1002/adsc.202000134

M3 - Article

JO - Advanced Synthesis & Catalysis

JF - Advanced Synthesis & Catalysis

SN - 1615-4169

ER -