Sulfenyl ynamides in gold catalysis: synthesis of oxo‐functionalised 4‐aminoimidazolyl fused compounds by intermolecular annulation reactions
Research output: Contribution to journal › Article › peer-review
Authors
Colleges, School and Institutes
Abstract
Functionalised N-heterocyclic pyridinium N-aminides have been designed and synthesised to evaluate a nitrenoid-based annulation strategy into imidazole-fused oxo-substituted frameworks of importance to medicinal and agrochemical discovery programmes. Sulfenyl substituted ynamides were identified as privileged reactants affording productive gold-catalysed annulation reactions with these and other nitrenoids. This annulation method provides selective and efficient access into geminally amino-sulfenyl substituted nitrogen heterocycles under mild reaction conditions. (Figure presented.).
Bibliographic note
Details
Original language | English |
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Pages (from-to) | 2503-2509 |
Number of pages | 7 |
Journal | Advanced Synthesis & Catalysis |
Volume | 362 |
Issue number | 12 |
Early online date | 24 Mar 2020 |
Publication status | Published - 15 Jun 2020 |
Keywords
- Annulations, Gold catalysis, Heterocycles, Sulfur, Ynamides