Sulfation pathways: Insights into steroid sulfation and desulfation pathways
Research output: Contribution to journal › Review article › peer-review
Colleges, School and Institutes
Sulfation and desulfation pathways represent highly dynamic ways of shuttling, repressing and re-activating steroid hormones, thus controlling their immense biological potency at the very heart of endocrinology. This theme currently experiences growing research interest from various sides, including, but not limited to, novel insights about phospho-adenosine-5'-phosphosulfate synthase and sulfotransferase function and regulation, novel analytics for steroid conjugate detection and quantification. Within this review, we will also define how sulfation pathways are ripe for drug development strategies, which have translational potential to treat a number of conditions, including chronic inflammatory diseases and steroid-dependent cancers.
|Number of pages||13|
|Journal||Journal of Molecular Endocrinology|
|Publication status||Published - 1 Aug 2018|
- adrenal hormones, androgens, DHEA, hormone action, steroid homones