Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth

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Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth. / Kepshire, Dax S; Davis, Scott C; Dehghani, Hamid; Paulsen, Keith D; Pogue, Brian W.

In: Applied Optics, Vol. 46, No. 10, 01.04.2007, p. 1669-78.

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Kepshire, Dax S ; Davis, Scott C ; Dehghani, Hamid ; Paulsen, Keith D ; Pogue, Brian W. / Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth. In: Applied Optics. 2007 ; Vol. 46, No. 10. pp. 1669-78.

Bibtex

@article{b7d04b76725349849cad3afa76334bd9,
title = "Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth",
abstract = "Subsurface tomography with diffuse light has been investigated with a noncontact approach to characterize the performance of absorption and fluorescence imaging. Using both simulations and experiments, the reconstruction of local subsurface heterogeneity is demonstrated, but the recovery of target size and fluorophore concentration is not linear when changes in depth occur, whereas the mean position of the object for experimental fluorescent and absorber targets is accurate to within 0.5 and 1.45 mm when located within the first 10 mm below the surface. Improvements in the linearity of the response with depth appear to remain challenging and may ultimately limit the approach to detection rather than characterization applications. However, increases in tissue curvature and/or the addition of prior information are expected to improve the linearity of the response. The potential for this type of imaging technique to serve as a surgical guide is highlighted.",
keywords = "Algorithms, Computer Simulation, Image Enhancement, Image Interpretation, Computer-Assisted, Microscopy, Fluorescence, Models, Biological, Nonlinear Dynamics, Phantoms, Imaging, Reproducibility of Results, Sensitivity and Specificity, Tomography, Optical",
author = "Kepshire, {Dax S} and Davis, {Scott C} and Hamid Dehghani and Paulsen, {Keith D} and Pogue, {Brian W}",
year = "2007",
month = apr,
day = "1",
language = "English",
volume = "46",
pages = "1669--78",
journal = "Applied Optics",
issn = "1559-128X",
publisher = "Optical Society of America",
number = "10",

}

RIS

TY - JOUR

T1 - Subsurface diffuse optical tomography can localize absorber and fluorescent objects but recovered image sensitivity is nonlinear with depth

AU - Kepshire, Dax S

AU - Davis, Scott C

AU - Dehghani, Hamid

AU - Paulsen, Keith D

AU - Pogue, Brian W

PY - 2007/4/1

Y1 - 2007/4/1

N2 - Subsurface tomography with diffuse light has been investigated with a noncontact approach to characterize the performance of absorption and fluorescence imaging. Using both simulations and experiments, the reconstruction of local subsurface heterogeneity is demonstrated, but the recovery of target size and fluorophore concentration is not linear when changes in depth occur, whereas the mean position of the object for experimental fluorescent and absorber targets is accurate to within 0.5 and 1.45 mm when located within the first 10 mm below the surface. Improvements in the linearity of the response with depth appear to remain challenging and may ultimately limit the approach to detection rather than characterization applications. However, increases in tissue curvature and/or the addition of prior information are expected to improve the linearity of the response. The potential for this type of imaging technique to serve as a surgical guide is highlighted.

AB - Subsurface tomography with diffuse light has been investigated with a noncontact approach to characterize the performance of absorption and fluorescence imaging. Using both simulations and experiments, the reconstruction of local subsurface heterogeneity is demonstrated, but the recovery of target size and fluorophore concentration is not linear when changes in depth occur, whereas the mean position of the object for experimental fluorescent and absorber targets is accurate to within 0.5 and 1.45 mm when located within the first 10 mm below the surface. Improvements in the linearity of the response with depth appear to remain challenging and may ultimately limit the approach to detection rather than characterization applications. However, increases in tissue curvature and/or the addition of prior information are expected to improve the linearity of the response. The potential for this type of imaging technique to serve as a surgical guide is highlighted.

KW - Algorithms

KW - Computer Simulation

KW - Image Enhancement

KW - Image Interpretation, Computer-Assisted

KW - Microscopy, Fluorescence

KW - Models, Biological

KW - Nonlinear Dynamics

KW - Phantoms, Imaging

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Tomography, Optical

M3 - Article

C2 - 17356609

VL - 46

SP - 1669

EP - 1678

JO - Applied Optics

JF - Applied Optics

SN - 1559-128X

IS - 10

ER -