Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome:: Capturing the Discrepancy

Oriana M. Bezzina; Peter Gallagher; Sheryl Mitchell; Simon J. Bowman; Bridget Griffiths; Victoria Hindmarsh; Ben Hargreaves; Elizabeth J. Price; Colin T. Pease; Paul Emery; Peter Lanyon; Michele Bombardieri; Nurhan Sutcliffe; Costantino Pitzalis; John Hunter; Monica Gupta; John McLaren; Anne M. Cooper; Marian Regan; Ian P. Giles; David Isenberg; Vadivelu Saravanan; David Coady; Bhaskar Dasgupta; Neil J. McHugh; Steven A. Young-Min; Robert J. Moots; Nagui Gendi; Mohammed Akil; Kirsten MacKay; W. Fai Ng; Lucy J. Robinson; Elalaine C. Bacabac; Kuntal Chakravarty; Shamin Lamabadusuriya; Constantino Pitzalis; Rashidat Adeniba; Andrea Richards; Saaeha Rauz; Sue Brailsford; Joanne Logan; Jacqueline Andrews; Alison McManus; Colin Pease; Alison Booth; Theodoros Dimitroulas; Lucy Kadiki; Daljit Kaur; George Kitas; Mark Lloyd; UK Primary Sjögren’s Syndrome Registry

doi:10.1002/acr.23165

Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy

Oriana M. Bezzina, Peter Gallagher, Sheryl Mitchell, Simon J. Bowman, Bridget Griffiths, Victoria Hindmarsh, Ben Hargreaves, Elizabeth J. Price, Colin T. Pease, Paul Emery, Peter Lanyon, Michele Bombardieri, Nurhan Sutcliffe, Costantino Pitzalis, John Hunter, Monica Gupta, John McLaren, Anne M. Cooper, Marian Regan, Ian P. GilesDavid Isenberg, Vadivelu Saravanan, David Coady, Bhaskar Dasgupta, Neil J. McHugh, Steven A. Young-Min, Robert J. Moots, Nagui Gendi, Mohammed Akil, Kirsten MacKay, W. Fai Ng, Lucy J. Robinson^*, Elalaine C. Bacabac, Kuntal Chakravarty, Shamin Lamabadusuriya, Constantino Pitzalis, Rashidat Adeniba, Andrea Richards, Saaeha Rauz, Sue Brailsford, Joanne Logan, Jacqueline Andrews, Alison McManus, Colin Pease, Alison Booth, Theodoros Dimitroulas, Lucy Kadiki, Daljit Kaur, George Kitas, Mark Lloyd, UK Primary Sjögren’s Syndrome Registry

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

124 Downloads (Pure)

Abstract

Objective: To develop a novel method for capturing the discrepancy between objective tests and subjective dryness symptoms (a sensitivity scale) and to explore predictors of dryness sensitivity. Methods: Archive data from the UK Primary Sjögren's Syndrome Registry (n = 688) were used. Patients were classified on a scale from −5 (stoical) to +5 (sensitive) depending on the degree of discrepancy between their objective and subjective symptoms classes. Sensitivity scores were correlated with demographic variables, disease-related factors, and symptoms of pain, fatigue, anxiety, and depression. Results: Patients were on average relatively stoical for both types of dryness symptoms (mean ± SD ocular dryness −0.42 ± 2.2 and −1.24 ± 1.6 oral dryness). Twenty-seven percent of patients were classified as sensitive to ocular dryness and 9% to oral dryness. Hierarchical regression analyses identified the strongest predictor of ocular dryness sensitivity to be self-reported pain and that of oral dryness sensitivity to be self-reported fatigue. Conclusion: Ocular and oral dryness sensitivity can be classified on a continuous scale. The 2 symptom types are predicted by different variables. A large number of factors remain to be explored that may impact symptom sensitivity in primary Sjögrenʼs syndrome, and the proposed method could be used to identify relatively sensitive and stoical patients for future studies.

Original language	English
Pages (from-to)	1714-1723
Number of pages	10
Journal	Arthritis Care and Research
Volume	69
Issue number	11
Early online date	19 Dec 2016
DOIs	https://doi.org/10.1002/acr.23165
Publication status	Published - 1 Nov 2017

ASJC Scopus subject areas

Rheumatology

Access to Document

10.1002/acr.23165Licence: Creative Commons: Attribution (CC BY)

Bezzina_et_al_Subjective_and_objective_measures_Arthritis_Care_&_Research_2016
Published in Arthritis Care & Research on 19/12/2016 DOI: 10.1002/acr.23165
Final published version, 174 KBLicence: Creative Commons: Attribution (CC BY)

https://onlinelibrary.wiley.com/doi/full/10.1002/acr.23165Licence: Creative Commons: Attribution (CC BY)

Cite this

Bezzina, O. M., Gallagher, P., Mitchell, S., Bowman, S. J., Griffiths, B., Hindmarsh, V., Hargreaves, B., Price, E. J., Pease, C. T., Emery, P., Lanyon, P., Bombardieri, M., Sutcliffe, N., Pitzalis, C., Hunter, J., Gupta, M., McLaren, J., Cooper, A. M., Regan, M., ... UK Primary Sjögren’s Syndrome Registry (2017). Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy. Arthritis Care and Research, 69(11), 1714-1723. Advance online publication. https://doi.org/10.1002/acr.23165

@article{b2963b9c1dcd4183abba21f70692c440,

title = "Subjective and Objective Measures of Dryness Symptoms in Primary Sj{\"o}gren's Syndrome:: Capturing the Discrepancy",

abstract = "Objective: To develop a novel method for capturing the discrepancy between objective tests and subjective dryness symptoms (a sensitivity scale) and to explore predictors of dryness sensitivity. Methods: Archive data from the UK Primary Sj{\"o}gren's Syndrome Registry (n = 688) were used. Patients were classified on a scale from −5 (stoical) to +5 (sensitive) depending on the degree of discrepancy between their objective and subjective symptoms classes. Sensitivity scores were correlated with demographic variables, disease-related factors, and symptoms of pain, fatigue, anxiety, and depression. Results: Patients were on average relatively stoical for both types of dryness symptoms (mean ± SD ocular dryness −0.42 ± 2.2 and −1.24 ± 1.6 oral dryness). Twenty-seven percent of patients were classified as sensitive to ocular dryness and 9% to oral dryness. Hierarchical regression analyses identified the strongest predictor of ocular dryness sensitivity to be self-reported pain and that of oral dryness sensitivity to be self-reported fatigue. Conclusion: Ocular and oral dryness sensitivity can be classified on a continuous scale. The 2 symptom types are predicted by different variables. A large number of factors remain to be explored that may impact symptom sensitivity in primary Sj{\"o}grenʼs syndrome, and the proposed method could be used to identify relatively sensitive and stoical patients for future studies.",

author = "Bezzina, {Oriana M.} and Peter Gallagher and Sheryl Mitchell and Bowman, {Simon J.} and Bridget Griffiths and Victoria Hindmarsh and Ben Hargreaves and Price, {Elizabeth J.} and Pease, {Colin T.} and Paul Emery and Peter Lanyon and Michele Bombardieri and Nurhan Sutcliffe and Costantino Pitzalis and John Hunter and Monica Gupta and John McLaren and Cooper, {Anne M.} and Marian Regan and Giles, {Ian P.} and David Isenberg and Vadivelu Saravanan and David Coady and Bhaskar Dasgupta and McHugh, {Neil J.} and Young-Min, {Steven A.} and Moots, {Robert J.} and Nagui Gendi and Mohammed Akil and Kirsten MacKay and Ng, {W. Fai} and Robinson, {Lucy J.} and Bacabac, {Elalaine C.} and Kuntal Chakravarty and Shamin Lamabadusuriya and Constantino Pitzalis and Rashidat Adeniba and Andrea Richards and Saaeha Rauz and Sue Brailsford and Joanne Logan and Jacqueline Andrews and Alison McManus and Colin Pease and Alison Booth and Theodoros Dimitroulas and Lucy Kadiki and Daljit Kaur and George Kitas and Mark Lloyd and {UK Primary Sj{\"o}gren{\textquoteright}s Syndrome Registry}",

year = "2017",

month = nov,

day = "1",

doi = "10.1002/acr.23165",

language = "English",

volume = "69",

pages = "1714--1723",

journal = "Arthritis Care and Research",

issn = "2151-464X",

publisher = "John Wiley & Sons",

number = "11",

}

Bezzina, OM, Gallagher, P, Mitchell, S, Bowman, SJ, Griffiths, B, Hindmarsh, V, Hargreaves, B, Price, EJ, Pease, CT, Emery, P, Lanyon, P, Bombardieri, M, Sutcliffe, N, Pitzalis, C, Hunter, J, Gupta, M, McLaren, J, Cooper, AM, Regan, M, Giles, IP, Isenberg, D, Saravanan, V, Coady, D, Dasgupta, B, McHugh, NJ, Young-Min, SA, Moots, RJ, Gendi, N, Akil, M, MacKay, K, Ng, WF, Robinson, LJ, Bacabac, EC, Chakravarty, K, Lamabadusuriya, S, Pitzalis, C, Adeniba, R, Richards, A, Rauz, S, Brailsford, S, Logan, J, Andrews, J, McManus, A, Pease, C, Booth, A, Dimitroulas, T, Kadiki, L, Kaur, D, Kitas, G, Lloyd, M & UK Primary Sjögren’s Syndrome Registry 2017, 'Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy', Arthritis Care and Research, vol. 69, no. 11, pp. 1714-1723. https://doi.org/10.1002/acr.23165

TY - JOUR

T1 - Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome:

T2 - Capturing the Discrepancy

AU - Bezzina, Oriana M.

AU - Gallagher, Peter

AU - Mitchell, Sheryl

AU - Bowman, Simon J.

AU - Griffiths, Bridget

AU - Hindmarsh, Victoria

AU - Hargreaves, Ben

AU - Price, Elizabeth J.

AU - Pease, Colin T.

AU - Emery, Paul

AU - Lanyon, Peter

AU - Bombardieri, Michele

AU - Sutcliffe, Nurhan

AU - Pitzalis, Costantino

AU - Hunter, John

AU - Gupta, Monica

AU - McLaren, John

AU - Cooper, Anne M.

AU - Regan, Marian

AU - Giles, Ian P.

AU - Isenberg, David

AU - Saravanan, Vadivelu

AU - Coady, David

AU - Dasgupta, Bhaskar

AU - McHugh, Neil J.

AU - Young-Min, Steven A.

AU - Moots, Robert J.

AU - Gendi, Nagui

AU - Akil, Mohammed

AU - MacKay, Kirsten

AU - Ng, W. Fai

AU - Robinson, Lucy J.

AU - Bacabac, Elalaine C.

AU - Chakravarty, Kuntal

AU - Lamabadusuriya, Shamin

AU - Pitzalis, Constantino

AU - Adeniba, Rashidat

AU - Richards, Andrea

AU - Rauz, Saaeha

AU - Brailsford, Sue

AU - Logan, Joanne

AU - Andrews, Jacqueline

AU - McManus, Alison

AU - Pease, Colin

AU - Booth, Alison

AU - Dimitroulas, Theodoros

AU - Kadiki, Lucy

AU - Kaur, Daljit

AU - Kitas, George

AU - Lloyd, Mark

AU - UK Primary Sjögren’s Syndrome Registry

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Objective: To develop a novel method for capturing the discrepancy between objective tests and subjective dryness symptoms (a sensitivity scale) and to explore predictors of dryness sensitivity. Methods: Archive data from the UK Primary Sjögren's Syndrome Registry (n = 688) were used. Patients were classified on a scale from −5 (stoical) to +5 (sensitive) depending on the degree of discrepancy between their objective and subjective symptoms classes. Sensitivity scores were correlated with demographic variables, disease-related factors, and symptoms of pain, fatigue, anxiety, and depression. Results: Patients were on average relatively stoical for both types of dryness symptoms (mean ± SD ocular dryness −0.42 ± 2.2 and −1.24 ± 1.6 oral dryness). Twenty-seven percent of patients were classified as sensitive to ocular dryness and 9% to oral dryness. Hierarchical regression analyses identified the strongest predictor of ocular dryness sensitivity to be self-reported pain and that of oral dryness sensitivity to be self-reported fatigue. Conclusion: Ocular and oral dryness sensitivity can be classified on a continuous scale. The 2 symptom types are predicted by different variables. A large number of factors remain to be explored that may impact symptom sensitivity in primary Sjögrenʼs syndrome, and the proposed method could be used to identify relatively sensitive and stoical patients for future studies.

AB - Objective: To develop a novel method for capturing the discrepancy between objective tests and subjective dryness symptoms (a sensitivity scale) and to explore predictors of dryness sensitivity. Methods: Archive data from the UK Primary Sjögren's Syndrome Registry (n = 688) were used. Patients were classified on a scale from −5 (stoical) to +5 (sensitive) depending on the degree of discrepancy between their objective and subjective symptoms classes. Sensitivity scores were correlated with demographic variables, disease-related factors, and symptoms of pain, fatigue, anxiety, and depression. Results: Patients were on average relatively stoical for both types of dryness symptoms (mean ± SD ocular dryness −0.42 ± 2.2 and −1.24 ± 1.6 oral dryness). Twenty-seven percent of patients were classified as sensitive to ocular dryness and 9% to oral dryness. Hierarchical regression analyses identified the strongest predictor of ocular dryness sensitivity to be self-reported pain and that of oral dryness sensitivity to be self-reported fatigue. Conclusion: Ocular and oral dryness sensitivity can be classified on a continuous scale. The 2 symptom types are predicted by different variables. A large number of factors remain to be explored that may impact symptom sensitivity in primary Sjögrenʼs syndrome, and the proposed method could be used to identify relatively sensitive and stoical patients for future studies.

UR - http://www.scopus.com/inward/record.url?scp=85030637588&partnerID=8YFLogxK

U2 - 10.1002/acr.23165

DO - 10.1002/acr.23165

M3 - Article

C2 - 27992710

AN - SCOPUS:85030637588

SN - 2151-464X

VL - 69

SP - 1714

EP - 1723

JO - Arthritis Care and Research

JF - Arthritis Care and Research

IS - 11

ER -

Subjective and Objective Measures of Dryness Symptoms in Primary Sjögren's Syndrome: Capturing the Discrepancy

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this