Structure determination of a steroid directly from powder diffraction data

Research output: Contribution to journalArticlepeer-review


  • Katerina Psallidas
  • Robert W. Lancaster
  • Susan E. Staniforth
  • Simon M. Cooper

Colleges, School and Institutes

External organisations

  • GlaxoSmithKline


We report the determination of the crystal structure of a new polymorph of the pharmaceutical material fluticasone propionate, which is obtained as a microcrystalline powder by a supercritical crystallization procedure; the structure was solved directly from powder diffraction data using our Genetic Algorithm technique (in which a population of trial structures evolves through well-defined procedures for mating, mutation and natural selection) and refined using Rietveld refinement techniques.


Original languageEnglish
Pages (from-to)1677-1678
Number of pages2
JournalChemical Communications
Issue number17
Publication statusPublished - 7 Sep 1999