Structure and function of active chromatin and DNase I hypersensitive sites

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

Chromatin is by its very nature a repressive environment which restricts the recruitment of transcription factors and acts as a barrier to polymerases. Therefore the complex process of gene activation must operate at two levels. In the first instance, localized chromatin decondensation and nucleosome displacement is required to make DNA accessible. Second, sequence-specific transcription factors need to recruit chromatin modifiers and remodellers to create a chromatin environment that permits the passage of polymerases. In this review I will discuss the chromatin structural changes that occur at active gene loci and at regulatory elements that exist as DNase I hypersensitive sites.

Bibliographic note

© 2011 The Author Journal compilation © 2011 FEBS.

Details

Original languageEnglish
Pages (from-to)2182-210
Number of pages29
JournalThe FEBS journal
Volume278
Issue number13
Early online date26 May 2011
Publication statusPublished - 15 Jun 2011

Keywords

  • Animals, Chromatin, Deoxyribonuclease I, Humans, Transcriptional Activation