Structure and function of active chromatin and DNase I hypersensitive sites
Research output: Contribution to journal › Article
Colleges, School and Institutes
Chromatin is by its very nature a repressive environment which restricts the recruitment of transcription factors and acts as a barrier to polymerases. Therefore the complex process of gene activation must operate at two levels. In the first instance, localized chromatin decondensation and nucleosome displacement is required to make DNA accessible. Second, sequence-specific transcription factors need to recruit chromatin modifiers and remodellers to create a chromatin environment that permits the passage of polymerases. In this review I will discuss the chromatin structural changes that occur at active gene loci and at regulatory elements that exist as DNase I hypersensitive sites.
© 2011 The Author Journal compilation © 2011 FEBS.
|Number of pages||29|
|Journal||The FEBS journal|
|Early online date||26 May 2011|
|Publication status||Published - 15 Jun 2011|
- Animals, Chromatin, Deoxyribonuclease I, Humans, Transcriptional Activation