Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species

Research output: Contribution to journalArticlepeer-review


  • Claudio Donati
  • N Luisa Hiller
  • Hervé Tettelin
  • Alessandro Muzzi
  • Nicholas J Croucher
  • Samuel V Angiuoli
  • Marco Oggioni
  • Julie C Dunning Hotopp
  • Fen Z Hu
  • David R Riley
  • Antonello Covacci
  • Stephen D Bentley
  • Morgens Kilian
  • Garth D Ehrlich
  • Rino Rappuoli
  • E Richard Moxon
  • Vega Masignani

Colleges, School and Institutes


Streptococcus pneumoniae is one of the most important causes of microbial diseases in humans. The genomes of 44 diverse strains of S. pneumoniae were analyzed and compared with strains of non-pathogenic streptococci of the Mitis group.


Original languageEnglish
Pages (from-to)R107
JournalGenome Biology
Issue number10
Publication statusPublished - 2010


  • DNA, Bacterial, Evolution, Molecular, Gene Conversion, Genes, Bacterial, Genetic Variation, Genome, Bacterial, Linkage Disequilibrium, Multigene Family, Phylogeny, Polymorphism, Single Nucleotide, Sequence Alignment, Sequence Analysis, DNA, Streptococcus mitis, Streptococcus pneumoniae, Virulence