Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation
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Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation. / Sun, Liang; Pitto-Barry, Anaïs; Kirby, Nigel; Schiller, Tara L; Sanchez, Ana M; Dyson, M Adam; Sloan, Jeremy; Wilson, Neil R; O'Reilly, Rachel K; Dove, Andrew P.
In: Nature Communications, Vol. 5, 5746, 17.12.2014.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation
AU - Sun, Liang
AU - Pitto-Barry, Anaïs
AU - Kirby, Nigel
AU - Schiller, Tara L
AU - Sanchez, Ana M
AU - Dyson, M Adam
AU - Sloan, Jeremy
AU - Wilson, Neil R
AU - O'Reilly, Rachel K
AU - Dove, Andrew P
PY - 2014/12/17
Y1 - 2014/12/17
N2 - Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H2O mixtures or in pure water at 65 °C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications.
AB - Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H2O mixtures or in pure water at 65 °C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications.
KW - Biocompatible Materials/chemistry
KW - Crystallization
KW - Delayed-Action Preparations
KW - Furans/chemistry
KW - Micelles
KW - Microscopy, Electron, Transmission
KW - Nanoparticles/chemistry
KW - Polyesters/chemistry
KW - Stereoisomerism
KW - Temperature
KW - Water/chemistry
U2 - 10.1038/ncomms6746
DO - 10.1038/ncomms6746
M3 - Article
C2 - 25517544
VL - 5
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 5746
ER -