Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation

Research output: Contribution to journalArticlepeer-review

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Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation. / Sun, Liang; Pitto-Barry, Anaïs; Kirby, Nigel; Schiller, Tara L; Sanchez, Ana M; Dyson, M Adam; Sloan, Jeremy; Wilson, Neil R; O'Reilly, Rachel K; Dove, Andrew P.

In: Nature Communications, Vol. 5, 5746, 17.12.2014.

Research output: Contribution to journalArticlepeer-review

Harvard

Sun, L, Pitto-Barry, A, Kirby, N, Schiller, TL, Sanchez, AM, Dyson, MA, Sloan, J, Wilson, NR, O'Reilly, RK & Dove, AP 2014, 'Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation', Nature Communications, vol. 5, 5746. https://doi.org/10.1038/ncomms6746

APA

Sun, L., Pitto-Barry, A., Kirby, N., Schiller, T. L., Sanchez, A. M., Dyson, M. A., Sloan, J., Wilson, N. R., O'Reilly, R. K., & Dove, A. P. (2014). Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation. Nature Communications, 5, [5746]. https://doi.org/10.1038/ncomms6746

Vancouver

Author

Sun, Liang ; Pitto-Barry, Anaïs ; Kirby, Nigel ; Schiller, Tara L ; Sanchez, Ana M ; Dyson, M Adam ; Sloan, Jeremy ; Wilson, Neil R ; O'Reilly, Rachel K ; Dove, Andrew P. / Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation. In: Nature Communications. 2014 ; Vol. 5.

Bibtex

@article{fac14aa901fb45e391029241a4637596,
title = "Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation",
abstract = "Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H2O mixtures or in pure water at 65 °C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications.",
keywords = "Biocompatible Materials/chemistry, Crystallization, Delayed-Action Preparations, Furans/chemistry, Micelles, Microscopy, Electron, Transmission, Nanoparticles/chemistry, Polyesters/chemistry, Stereoisomerism, Temperature, Water/chemistry",
author = "Liang Sun and Ana{\"i}s Pitto-Barry and Nigel Kirby and Schiller, {Tara L} and Sanchez, {Ana M} and Dyson, {M Adam} and Jeremy Sloan and Wilson, {Neil R} and O'Reilly, {Rachel K} and Dove, {Andrew P}",
year = "2014",
month = dec,
day = "17",
doi = "10.1038/ncomms6746",
language = "English",
volume = "5",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Structural reorganization of cylindrical nanoparticles triggered by polylactide stereocomplexation

AU - Sun, Liang

AU - Pitto-Barry, Anaïs

AU - Kirby, Nigel

AU - Schiller, Tara L

AU - Sanchez, Ana M

AU - Dyson, M Adam

AU - Sloan, Jeremy

AU - Wilson, Neil R

AU - O'Reilly, Rachel K

AU - Dove, Andrew P

PY - 2014/12/17

Y1 - 2014/12/17

N2 - Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H2O mixtures or in pure water at 65 °C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications.

AB - Co-crystallization of polymers with different configurations/tacticities provides access to materials with enhanced performance. The stereocomplexation of isotactic poly(L-lactide) and poly(D-lactide) has led to improved properties compared with each homochiral material. Herein, we report the preparation of stereocomplex micelles from a mixture of poly(L-lactide)-b-poly(acrylic acid) and poly(D-lactide)-b-poly(acrylic acid) diblock copolymers in water via crystallization-driven self-assembly. During the formation of these stereocomplex micelles, an unexpected morphological transition results in the formation of dense crystalline spherical micelles rather than cylinders. Furthermore, mixture of cylinders with opposite homochirality in either THF/H2O mixtures or in pure water at 65 °C leads to disassembly into stereocomplexed spherical micelles. Similarly, a transition is also observed in a related PEO-b-PLLA/PEO-b-PDLA system, demonstrating wider applicability. This new mechanism for morphological reorganization, through competitive crystallization and stereocomplexation and without the requirement for an external stimulus, allows for new opportunities in controlled release and delivery applications.

KW - Biocompatible Materials/chemistry

KW - Crystallization

KW - Delayed-Action Preparations

KW - Furans/chemistry

KW - Micelles

KW - Microscopy, Electron, Transmission

KW - Nanoparticles/chemistry

KW - Polyesters/chemistry

KW - Stereoisomerism

KW - Temperature

KW - Water/chemistry

U2 - 10.1038/ncomms6746

DO - 10.1038/ncomms6746

M3 - Article

C2 - 25517544

VL - 5

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 5746

ER -