Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry study

Thomas Villemonteix; Stéphane A De Brito; Hichem Slama; Martin Kavec; Danielle Balériaux; Thierry Metens; Simon Baijot; Alison Mary; Nicolas Ramoz; Mathilde Septier; Philip Gorwood; Philippe Peigneux; Isabelle Massat

doi:10.3109/15622975.2014.984629

Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry study

Thomas Villemonteix, Stéphane A De Brito, Hichem Slama, Martin Kavec, Danielle Balériaux, Thierry Metens, Simon Baijot, Alison Mary, Nicolas Ramoz, Mathilde Septier, Philip Gorwood, Philippe Peigneux, Isabelle Massat

Psychology

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

OBJECTIVES: The Val158-allele of the catechol-O-methyltransferase (COMT) Val158Met (rs4680) functional polymorphism has been identified as a risk factor for antisocial behaviour in attention-deficit/hyperactivity disorder (ADHD). Here, we used voxel-based morphometry to investigate the effects of Val158Met polymorphism on grey matter (GM) volumes in a sample of 7-13-year-old children.

METHODS: MRI and genotype data were obtained for 38 children with combined-type ADHD and 24 typically developing (TD) children. Four regions of interest were identified: striatum, cerebellum, temporal lobe and inferior frontal gyrus (IFG).

RESULTS: When compared to TD children, those with ADHD had a significant decrease of GM volume in the IFG. Volume in this region was negatively correlated with ratings of hyperactivity/impulsivity symptoms. Furthermore, the smaller GM volume in the IFG was attributed to the presence of the Met158-allele, as only children with ADHD carrying a Met158-allele exhibited such decrease in the IFG. Children with ADHD homozygotes for the Val158-allele presented increased GM volume in the caudate nucleus when compared with TD children.

CONCLUSIONS: This study provides the first evidence of a modulation of ADHD-related GM volume alterations by Val158Met in two key regions, possibly mediating the relationship between Val158Met polymorphism and antisocial behaviour in children with ADHD.

Original language	English
Pages (from-to)	190-9
Number of pages	10
Journal	World Journal of Biological Psychiatry
Volume	16
Issue number	3
DOIs	https://doi.org/10.3109/15622975.2014.984629
Publication status	Published - Apr 2015

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Villemonteix, T., De Brito, S. A., Slama, H., Kavec, M., Balériaux, D., Metens, T., Baijot, S., Mary, A., Ramoz, N., Septier, M., Gorwood, P., Peigneux, P., & Massat, I. (2015). Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry study. World Journal of Biological Psychiatry, 16(3), 190-9. https://doi.org/10.3109/15622975.2014.984629

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title = "Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry study",

abstract = "OBJECTIVES: The Val158-allele of the catechol-O-methyltransferase (COMT) Val158Met (rs4680) functional polymorphism has been identified as a risk factor for antisocial behaviour in attention-deficit/hyperactivity disorder (ADHD). Here, we used voxel-based morphometry to investigate the effects of Val158Met polymorphism on grey matter (GM) volumes in a sample of 7-13-year-old children.METHODS: MRI and genotype data were obtained for 38 children with combined-type ADHD and 24 typically developing (TD) children. Four regions of interest were identified: striatum, cerebellum, temporal lobe and inferior frontal gyrus (IFG).RESULTS: When compared to TD children, those with ADHD had a significant decrease of GM volume in the IFG. Volume in this region was negatively correlated with ratings of hyperactivity/impulsivity symptoms. Furthermore, the smaller GM volume in the IFG was attributed to the presence of the Met158-allele, as only children with ADHD carrying a Met158-allele exhibited such decrease in the IFG. Children with ADHD homozygotes for the Val158-allele presented increased GM volume in the caudate nucleus when compared with TD children.CONCLUSIONS: This study provides the first evidence of a modulation of ADHD-related GM volume alterations by Val158Met in two key regions, possibly mediating the relationship between Val158Met polymorphism and antisocial behaviour in children with ADHD.",

author = "Thomas Villemonteix and {De Brito}, {St{\'e}phane A} and Hichem Slama and Martin Kavec and Danielle Bal{\'e}riaux and Thierry Metens and Simon Baijot and Alison Mary and Nicolas Ramoz and Mathilde Septier and Philip Gorwood and Philippe Peigneux and Isabelle Massat",

year = "2015",

month = apr,

doi = "10.3109/15622975.2014.984629",

language = "English",

volume = "16",

pages = "190--9",

journal = "World Journal of Biological Psychiatry",

issn = "1562-2975",

publisher = "Taylor & Francis",

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Villemonteix, T, De Brito, SA, Slama, H, Kavec, M, Balériaux, D, Metens, T, Baijot, S, Mary, A, Ramoz, N, Septier, M, Gorwood, P, Peigneux, P & Massat, I 2015, 'Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry study', World Journal of Biological Psychiatry, vol. 16, no. 3, pp. 190-9. https://doi.org/10.3109/15622975.2014.984629

TY - JOUR

T1 - Structural correlates of COMT Val158Met polymorphism in childhood ADHD

T2 - a voxel-based morphometry study

AU - Villemonteix, Thomas

AU - De Brito, Stéphane A

AU - Slama, Hichem

AU - Kavec, Martin

AU - Balériaux, Danielle

AU - Metens, Thierry

AU - Baijot, Simon

AU - Mary, Alison

AU - Ramoz, Nicolas

AU - Septier, Mathilde

AU - Gorwood, Philip

AU - Peigneux, Philippe

AU - Massat, Isabelle

PY - 2015/4

Y1 - 2015/4

N2 - OBJECTIVES: The Val158-allele of the catechol-O-methyltransferase (COMT) Val158Met (rs4680) functional polymorphism has been identified as a risk factor for antisocial behaviour in attention-deficit/hyperactivity disorder (ADHD). Here, we used voxel-based morphometry to investigate the effects of Val158Met polymorphism on grey matter (GM) volumes in a sample of 7-13-year-old children.METHODS: MRI and genotype data were obtained for 38 children with combined-type ADHD and 24 typically developing (TD) children. Four regions of interest were identified: striatum, cerebellum, temporal lobe and inferior frontal gyrus (IFG).RESULTS: When compared to TD children, those with ADHD had a significant decrease of GM volume in the IFG. Volume in this region was negatively correlated with ratings of hyperactivity/impulsivity symptoms. Furthermore, the smaller GM volume in the IFG was attributed to the presence of the Met158-allele, as only children with ADHD carrying a Met158-allele exhibited such decrease in the IFG. Children with ADHD homozygotes for the Val158-allele presented increased GM volume in the caudate nucleus when compared with TD children.CONCLUSIONS: This study provides the first evidence of a modulation of ADHD-related GM volume alterations by Val158Met in two key regions, possibly mediating the relationship between Val158Met polymorphism and antisocial behaviour in children with ADHD.

AB - OBJECTIVES: The Val158-allele of the catechol-O-methyltransferase (COMT) Val158Met (rs4680) functional polymorphism has been identified as a risk factor for antisocial behaviour in attention-deficit/hyperactivity disorder (ADHD). Here, we used voxel-based morphometry to investigate the effects of Val158Met polymorphism on grey matter (GM) volumes in a sample of 7-13-year-old children.METHODS: MRI and genotype data were obtained for 38 children with combined-type ADHD and 24 typically developing (TD) children. Four regions of interest were identified: striatum, cerebellum, temporal lobe and inferior frontal gyrus (IFG).RESULTS: When compared to TD children, those with ADHD had a significant decrease of GM volume in the IFG. Volume in this region was negatively correlated with ratings of hyperactivity/impulsivity symptoms. Furthermore, the smaller GM volume in the IFG was attributed to the presence of the Met158-allele, as only children with ADHD carrying a Met158-allele exhibited such decrease in the IFG. Children with ADHD homozygotes for the Val158-allele presented increased GM volume in the caudate nucleus when compared with TD children.CONCLUSIONS: This study provides the first evidence of a modulation of ADHD-related GM volume alterations by Val158Met in two key regions, possibly mediating the relationship between Val158Met polymorphism and antisocial behaviour in children with ADHD.

U2 - 10.3109/15622975.2014.984629

DO - 10.3109/15622975.2014.984629

M3 - Article

C2 - 25495556

SN - 1562-2975

VL - 16

SP - 190

EP - 199

JO - World Journal of Biological Psychiatry

JF - World Journal of Biological Psychiatry

IS - 3

ER -

Structural correlates of COMT Val158Met polymorphism in childhood ADHD: a voxel-based morphometry study

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