Stromal cells in chronic inflammation and tertiary lymphoid organ formation

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@article{33e5697b8d464f11a4050fdeab9a5a50,
title = "Stromal cells in chronic inflammation and tertiary lymphoid organ formation",
abstract = "Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflammatory cells within inflamed tissues. Furthermore, at many sites of chronic inflammation, structures that mimic secondary lymphoid tissues are observed, suggesting that chronic inflammation and lymphoid tissue formation share common activation programs. Similarly, blood and lymphatic endothelial cells contribute to tissue homeostasis and disease persistence in chronic inflammation. This review highlights our increasing understanding of the role of stromal cells in inflammation and summarizes the novel immunological role that stromal cells exert in the persistence of inflammatory diseases. ",
keywords = "stromal cells, fibroblast, chronic inflammation, persistence",
author = "Christopher Buckley and Francesca Barone and Saba Nayar and Cecile Benezech and Jorge Caamano",
year = "2015",
month = mar,
doi = "10.1146/annurev-immunol-032713-120252",
language = "English",
volume = "33",
pages = "715--745",
journal = "Annual review of immunology",
issn = "0732-0582",
publisher = "Annual Reviews",

}

RIS

TY - JOUR

T1 - Stromal cells in chronic inflammation and tertiary lymphoid organ formation

AU - Buckley, Christopher

AU - Barone, Francesca

AU - Nayar, Saba

AU - Benezech, Cecile

AU - Caamano, Jorge

PY - 2015/3

Y1 - 2015/3

N2 - Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflammatory cells within inflamed tissues. Furthermore, at many sites of chronic inflammation, structures that mimic secondary lymphoid tissues are observed, suggesting that chronic inflammation and lymphoid tissue formation share common activation programs. Similarly, blood and lymphatic endothelial cells contribute to tissue homeostasis and disease persistence in chronic inflammation. This review highlights our increasing understanding of the role of stromal cells in inflammation and summarizes the novel immunological role that stromal cells exert in the persistence of inflammatory diseases.

AB - Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflammatory cells within inflamed tissues. Furthermore, at many sites of chronic inflammation, structures that mimic secondary lymphoid tissues are observed, suggesting that chronic inflammation and lymphoid tissue formation share common activation programs. Similarly, blood and lymphatic endothelial cells contribute to tissue homeostasis and disease persistence in chronic inflammation. This review highlights our increasing understanding of the role of stromal cells in inflammation and summarizes the novel immunological role that stromal cells exert in the persistence of inflammatory diseases.

KW - stromal cells

KW - fibroblast

KW - chronic inflammation

KW - persistence

U2 - 10.1146/annurev-immunol-032713-120252

DO - 10.1146/annurev-immunol-032713-120252

M3 - Article

VL - 33

SP - 715

EP - 745

JO - Annual review of immunology

JF - Annual review of immunology

SN - 0732-0582

ER -