Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin

J R Canvin; J C Paton; G J Boulnois; P W Andrew; T J Mitchell

doi:10.1006/mpat.1996.0098

Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin

J R Canvin, J C Paton, G J Boulnois, P W Andrew, T J Mitchell

Microbiology and Infection

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Pneumococci are described as alpha-haemolytic but under certain circumstances they produce zones of beta-haemolysis on blood-containing medium. This observation was investigated using wild type strains and a genetically-modified strain unable to produce the haemolytic toxin, pneumolysin. beta-haemolysis was produced by all pneumococci tested. It was not inhibited by anti-pneumolysin antibody but could be inactivated by cholesterol. These data confirm that pneumococci elaborate a second haemolysin, distinct from pneumolysin.

Original language	English
Pages (from-to)	129-32
Number of pages	4
Journal	Microbial Pathogenesis
Volume	22
Issue number	3
DOIs	https://doi.org/10.1006/mpat.1996.0098
Publication status	Published - Mar 1997

Keywords

Antibodies, Bacterial
Bacterial Proteins
Cholesterol
Escherichia coli
Hemolysin Proteins
Hemolysis
Streptococcus
Streptococcus pneumoniae
Streptolysins

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10.1006/mpat.1996.0098

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title = "Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin",

abstract = "Pneumococci are described as alpha-haemolytic but under certain circumstances they produce zones of beta-haemolysis on blood-containing medium. This observation was investigated using wild type strains and a genetically-modified strain unable to produce the haemolytic toxin, pneumolysin. beta-haemolysis was produced by all pneumococci tested. It was not inhibited by anti-pneumolysin antibody but could be inactivated by cholesterol. These data confirm that pneumococci elaborate a second haemolysin, distinct from pneumolysin.",

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year = "1997",

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T1 - Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin

AU - Canvin, J R

AU - Paton, J C

AU - Boulnois, G J

AU - Andrew, P W

AU - Mitchell, T J

PY - 1997/3

Y1 - 1997/3

N2 - Pneumococci are described as alpha-haemolytic but under certain circumstances they produce zones of beta-haemolysis on blood-containing medium. This observation was investigated using wild type strains and a genetically-modified strain unable to produce the haemolytic toxin, pneumolysin. beta-haemolysis was produced by all pneumococci tested. It was not inhibited by anti-pneumolysin antibody but could be inactivated by cholesterol. These data confirm that pneumococci elaborate a second haemolysin, distinct from pneumolysin.

AB - Pneumococci are described as alpha-haemolytic but under certain circumstances they produce zones of beta-haemolysis on blood-containing medium. This observation was investigated using wild type strains and a genetically-modified strain unable to produce the haemolytic toxin, pneumolysin. beta-haemolysis was produced by all pneumococci tested. It was not inhibited by anti-pneumolysin antibody but could be inactivated by cholesterol. These data confirm that pneumococci elaborate a second haemolysin, distinct from pneumolysin.

KW - Antibodies, Bacterial

KW - Bacterial Proteins

KW - Cholesterol

KW - Escherichia coli

KW - Hemolysin Proteins

KW - Hemolysis

KW - Streptococcus

KW - Streptococcus pneumoniae

KW - Streptolysins

U2 - 10.1006/mpat.1996.0098

DO - 10.1006/mpat.1996.0098

M3 - Article

C2 - 9075215

SN - 0882-4010

VL - 22

SP - 129

EP - 132

JO - Microbial Pathogenesis

JF - Microbial Pathogenesis

IS - 3

ER -

Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin

Abstract

Keywords

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