Streptococcus pneumoniae produces a second haemolysin that is distinct from pneumolysin

Research output: Contribution to journalArticlepeer-review


Colleges, School and Institutes


Pneumococci are described as alpha-haemolytic but under certain circumstances they produce zones of beta-haemolysis on blood-containing medium. This observation was investigated using wild type strains and a genetically-modified strain unable to produce the haemolytic toxin, pneumolysin. beta-haemolysis was produced by all pneumococci tested. It was not inhibited by anti-pneumolysin antibody but could be inactivated by cholesterol. These data confirm that pneumococci elaborate a second haemolysin, distinct from pneumolysin.


Original languageEnglish
Pages (from-to)129-32
Number of pages4
JournalMicrobial Pathogenesis
Issue number3
Publication statusPublished - Mar 1997


  • Antibodies, Bacterial, Bacterial Proteins, Cholesterol, Escherichia coli, Hemolysin Proteins, Hemolysis, Streptococcus, Streptococcus pneumoniae, Streptolysins