Steroidsulfatierung – von Sexual hormonen und neuen Krebsmedikamenten

Hendrik Reuper; Jonathan Wolf Mueller

doi:10.1007/s12268-016-0750-8

Steroidsulfatierung – von Sexual hormonen und neuen Krebsmedikamenten

Hendrik Reuper, Jonathan Wolf Mueller

Metabolism and Systems Research

Research output: Contribution to journal › Article › peer-review

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Abstract

In healthy human physiology, several steroid hormones are regulated in a dynamic equilibrium between sulfation and desulfation reactions. Inhibitors of steroid desulfation may soon enter clinical practice in cancer treatment. Sulfation pathways also include sulfate activation and transfer. Targeting the enzymes involved here may be another pharmacological strategy to boost sulfation pathways.

Original language	German
Pages (from-to)	717-719
Journal	BioSpektrum
Volume	22
Issue number	7
Early online date	15 Nov 2016
DOIs	https://doi.org/10.1007/s12268-016-0750-8
Publication status	Published - Nov 2016

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10.1007/s12268-016-0750-8Licence: None: All rights reserved

Mueller_Steroidsulfatierung_BIOspektrum_2016
Eligibility for repository: Checked on 30/11/2016
Accepted author manuscript, 725 KBLicence: None: All rights reserved

Cite this

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abstract = "In healthy human physiology, several steroid hormones are regulated in a dynamic equilibrium between sulfation and desulfation reactions. Inhibitors of steroid desulfation may soon enter clinical practice in cancer treatment. Sulfation pathways also include sulfate activation and transfer. Targeting the enzymes involved here may be another pharmacological strategy to boost sulfation pathways.",

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AB - In healthy human physiology, several steroid hormones are regulated in a dynamic equilibrium between sulfation and desulfation reactions. Inhibitors of steroid desulfation may soon enter clinical practice in cancer treatment. Sulfation pathways also include sulfate activation and transfer. Targeting the enzymes involved here may be another pharmacological strategy to boost sulfation pathways.

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