Stem cells for liver regeneration

Research output: Contribution to journalArticlepeer-review

Colleges, School and Institutes

Abstract

The liver has a unique capacity to repair following injury, which is largely achieved by proliferation of hepatocytes. However, in situations of chronic or overwhelming liver injury, additional repair mechanisms, namely liver progenitor or oval cells, are activated. These cells, located in the canals of Hering, express markers for both hepatocytes and biliary cells and have the capacity to differentiate down both hepatocyte and biliary lineages. Previous work has suggested that the administration of autologous or allogeneic cell therapies such as haematopoietic or mesenchymal stem cells can augment liver repair by either stimulating endogenous repair mechanisms or by suppressing ongoing damage. A better understanding of how cell therapies can promote liver regeneration will lead to the refinement of these therapeutic approaches and also develop new pharmacological agents for liver repair.

Bibliographic note

© The Author 2014. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Details

Original languageEnglish
Pages (from-to)417-21
Number of pages5
JournalQJM
Volume107
Issue number6
Publication statusPublished - Jun 2014

Keywords

  • Granulocyte Colony-Stimulating Factor, Hematopoietic Stem Cell Transplantation, Humans, Liver Diseases, Liver Regeneration, Mesenchymal Stem Cell Transplantation, Stem Cell Transplantation, Stem Cells