Starch/poly(glycerol-adipate) nanocomposites: A novel oral drug delivery device

Research output: Contribution to journalArticlepeer-review

Authors

  • Ambra Vestri
  • Robert Cavanagh
  • Ioanna D. Styliari
  • Carlos Sanders
  • Silvia Schenone
  • Vincenzo Taresco
  • Rasmus R. Jakobsen
  • Steven M. Howdle
  • Francesca Musumeci
  • Domenico Sagnelli

Colleges, School and Institutes

External organisations

  • University of Nottingham
  • University of Hertfordshire
  • CNRS-CEA
  • University of Genoa
  • University of Copenhagen

Abstract

Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsulate active ingredients, with encouraging perspectives for drug delivery purposes. Starch is a versatile, inexpensive, and abundant polysaccharide that can be effectively applied as a bio-scaffold for other molecules in order to enrich it with new appealing properties. In this work, the combination of PGA NPs and starch films proved to be a suitable biopolymeric matrix carrier for the controlled release preparation of hydrophobic drugs. Dynamic Light Scattering (DLS) was used to determine the size of drug-loaded PGA NPs, while the improvement of the apparent drug water solubility was assessed by UV-vis spectroscopy. In vitro biological assays were performed against cancer cell lines and bacteria strains to confirm that drug-loaded PGA NPs maintained the effective activity of the therapeutic agents. Dye-conjugated PGA was then exploited to track the NP release profile during the starch/PGA nanocomposite film digestion, which was assessed using digestion models mimicking physiological conditions. The collected data provide a clear indication of the suitability of our biodegradable carrier system for oral drug delivery.

Details

Original languageEnglish
Article number125
JournalCoatings
Volume10
Issue number2
Publication statusPublished - 1 Feb 2020

Keywords

  • Biocompatible, Biomaterial, Drug delivery, Nanocomposites, Nanoparticles, Poly(glycerol-adipate), Polymer, Starch