Stabilisation and Target Delivery of Nattokinase Using Compression Coating

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Stabilisation and Target Delivery of Nattokinase Using Compression Coating. / Law, Ning; Zhang, Zhibing.

In: Drug Development and Industrial Pharmacy, Vol. 33, No. 5, 01.05.2007, p. 495-503.

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@article{c84524a000284c60bd72ecb1037d325f,
title = "Stabilisation and Target Delivery of Nattokinase Using Compression Coating",
abstract = "The aim of the work is to develop a new formulation in order to stabilize a nutraceutical enzyme Nattokinase ( NKCP) in powders and to control its release rate when it passes through the gastrointestinal tract of human. NKCP powders were first compacted into a tablet, which was then coated with a mixture of an enteric material Eudragit (R) L100-55 (EL100-55) and Hydroxypropylcellulose (HPC) by direct compression. The activity of the enzyme was determined using amidolytic assay and its release rates in artificial gastric juice and an intestinal fluid were quantified using bicinchoninic acid assay. Results have shown that the activity of NKCP was pressure independent and the coated tablets protected NKCP from being denatured in the gastric juice, and realized its controlled release to the intestine based on in vitro experiments.",
author = "Ning Law and Zhibing Zhang",
year = "2007",
month = may,
day = "1",
doi = "10.1080/03639040601050247",
language = "English",
volume = "33",
pages = "495--503",
journal = "Drug Development and Industrial Pharmacy",
issn = "0363-9045",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - Stabilisation and Target Delivery of Nattokinase Using Compression Coating

AU - Law, Ning

AU - Zhang, Zhibing

PY - 2007/5/1

Y1 - 2007/5/1

N2 - The aim of the work is to develop a new formulation in order to stabilize a nutraceutical enzyme Nattokinase ( NKCP) in powders and to control its release rate when it passes through the gastrointestinal tract of human. NKCP powders were first compacted into a tablet, which was then coated with a mixture of an enteric material Eudragit (R) L100-55 (EL100-55) and Hydroxypropylcellulose (HPC) by direct compression. The activity of the enzyme was determined using amidolytic assay and its release rates in artificial gastric juice and an intestinal fluid were quantified using bicinchoninic acid assay. Results have shown that the activity of NKCP was pressure independent and the coated tablets protected NKCP from being denatured in the gastric juice, and realized its controlled release to the intestine based on in vitro experiments.

AB - The aim of the work is to develop a new formulation in order to stabilize a nutraceutical enzyme Nattokinase ( NKCP) in powders and to control its release rate when it passes through the gastrointestinal tract of human. NKCP powders were first compacted into a tablet, which was then coated with a mixture of an enteric material Eudragit (R) L100-55 (EL100-55) and Hydroxypropylcellulose (HPC) by direct compression. The activity of the enzyme was determined using amidolytic assay and its release rates in artificial gastric juice and an intestinal fluid were quantified using bicinchoninic acid assay. Results have shown that the activity of NKCP was pressure independent and the coated tablets protected NKCP from being denatured in the gastric juice, and realized its controlled release to the intestine based on in vitro experiments.

U2 - 10.1080/03639040601050247

DO - 10.1080/03639040601050247

M3 - Article

VL - 33

SP - 495

EP - 503

JO - Drug Development and Industrial Pharmacy

JF - Drug Development and Industrial Pharmacy

SN - 0363-9045

IS - 5

ER -