ST273 carbapenem-resistant Klebsiella pneumoniae carrying blaNDM-1 and blaIMP-4

Liu Lu; Yu Feng; Haiyan Long; Alan McNally; Zhiyong Zong

doi:10.1128/AAC.00160-18

ST273 carbapenem-resistant Klebsiella pneumoniae carrying bla_NDM-1 and bla_IMP-4

Liu Lu, Yu Feng, Haiyan Long, Alan McNally, Zhiyong Zong

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Abstract

A carbapenem-resistant Klebsiella pneumoniae was recovered from human blood. Its whole genome sequence was obtained using both Illumina and long-read MinION sequencing. The strain belongs to ST273, which has been found recently and caused an outbreak in Southeast Asia. It has two carbapenemase genes blaNDM-1 (carried by an ST7 IncN self-transmissible plasmid) and blaIMP-4 (located on an self-transmissible IncHI5 plasmid). Non-KPC-producing ST237 may represent a lineage of carbapenem-resistant K. pneumoniae, which warrants further monitoring.

Original language	English
Journal	Antimicrobial Agents and Chemotherapy
Early online date	2 Apr 2018
DOIs	https://doi.org/10.1128/AAC.00160-18
Publication status	E-pub ahead of print - 2 Apr 2018

Keywords

Journal Article

Access to Document

10.1128/AAC.00160-18Licence: None: All rights reserved

Lu_et_al_ST273_carbapenem-resistant_klebsiella_AAC_2018
Published in Antimicrobial Agents and Chemotherapy on 02/04/2018 DOI: 10.1128/AAC.00160-18
Accepted author manuscript, 9.13 MBLicence: Other (please specify with Rights Statement)

Cite this

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abstract = "A carbapenem-resistant Klebsiella pneumoniae was recovered from human blood. Its whole genome sequence was obtained using both Illumina and long-read MinION sequencing. The strain belongs to ST273, which has been found recently and caused an outbreak in Southeast Asia. It has two carbapenemase genes blaNDM-1 (carried by an ST7 IncN self-transmissible plasmid) and blaIMP-4 (located on an self-transmissible IncHI5 plasmid). Non-KPC-producing ST237 may represent a lineage of carbapenem-resistant K. pneumoniae, which warrants further monitoring.",

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