Sporogenesis and toxin A production by Clostridium difficile

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The kinetics of spore production by Clostridium difficile were not paralleled by release of C. difficile toxin A in vitro. Toxin A was not found to be associated with either purified whole spores or spore coats. Residual traces of toxin A detected in spore contents were almost certainly derived from contaminating vegetative cell debris. Thus, toxin A is unlikely to be a spore constituent or associated with sporogenesis.


Original languageEnglish
Pages (from-to)33-8
Number of pages6
JournalJournal of Medical Microbiology
Issue number1
Publication statusPublished - Aug 1986


  • Bacterial Toxins, Clostridium, Enterotoxins, Kinetics, Spores, Bacterial, Ultrasonics