Speeding up the evaluation of new agents in cancer

Research output: Contribution to journalEditorial

Authors

  • MKB Parmar
  • FMS Barthel
  • M Sydes
  • R Langley
  • R Kaplan
  • E Eisenhauer
  • M Brady
  • MA Bookman
  • AM Swart
  • W Qian
  • P Royston

Colleges, School and Institutes

Abstract

Despite both the increase in basic biologic knowledge and the fact that many new agents have reached various stages of development during the last 10 years, the number of new treatments that have been approved for patients has not increased as expected. We propose the multi-arm, multi-stage trial design as a way to evaluate treatments faster and more efficiently than current standard trial designs. By using intermediate outcomes and testing a number of new agents (and combinations) simultaneously, the new design requires fewer patients. Three trials using this methodology are presented.

Details

Original languageEnglish
Pages (from-to)1204-1214
Number of pages11
JournalJournal of the National Cancer Institute
Volume100
Issue number17
Publication statusPublished - 1 Sep 2008