Speeding up the evaluation of new agents in cancer
Research output: Contribution to journal › Editorial
Colleges, School and Institutes
Despite both the increase in basic biologic knowledge and the fact that many new agents have reached various stages of development during the last 10 years, the number of new treatments that have been approved for patients has not increased as expected. We propose the multi-arm, multi-stage trial design as a way to evaluate treatments faster and more efficiently than current standard trial designs. By using intermediate outcomes and testing a number of new agents (and combinations) simultaneously, the new design requires fewer patients. Three trials using this methodology are presented.
|Number of pages||11|
|Journal||Journal of the National Cancer Institute|
|Publication status||Published - 1 Sep 2008|