Species-specific antifungal activity of blue light

Research output: Contribution to journalArticlepeer-review


  • Robin May
  • Wioleta Trzaska
  • Helen Wrigley
  • Joanne E Thwaite

Colleges, School and Institutes

External organisations

  • School of Biosciences, University of Birmingham
  • Dstl


Fungal pathogens represent a significant threat to immunocompromised patients or individuals with traumatic injury. Strategies to efficiently remove fungal spores from hospital surfaces and, ideally, patient skin thus offer the prospect of dramatically reducing infections in at-risk patients. Photodynamic inactivation of microbial cells using light holds considerable potential as a non-invasive, minimally destructive disinfection strategy. Recent data indicate that high-intensity blue light effectively removes bacteria from surfaces, but its efficacy against fungi has not been fully tested. Here we test a wide range of fungi that are pathogenic to humans and demonstrate that blue light is effective against some, but not all, fungal species. We additionally note that secondary heating effects are a previously unrecognized confounding factor in establishing the antimicrobial activity of blue light. Thus blue light holds promise for the sterilization of clinical surfaces, but requires further optimization prior to widespread use.


Original languageEnglish
Pages (from-to)4605
JournalScientific Reports
Issue number1
Publication statusPublished - 4 Jul 2017


  • fungal pathogen, Treatment, Antifungal Agents, Antibiotic therapy, Wound healing